All Phenotypes Atxn1<tm2Zuk> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Atxn1^tm2Zuk
targeted mutation 2, Martin M Matzuk
MGI:2386669

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Atxn1^tm2Zuk/Atxn1^tm2Zuk	either: (involves: 129S/SvEv) or (involves: 129S7/SvEvBrd * C57BL/6)	MGI:3841064

Allelic Composition	Atxn1^tm2Zuk/Atxn1^tm2Zuk
Genetic Background	either: (involves: 129S/SvEv) or (involves: 129S7/SvEvBrd * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atxn1^tm2Zuk mutation (0 available); any Atxn1 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired coordination ( J:61398 )

• rotarod performance deteriorates with age

• normal at 3 months, slightly deficient at 6 months, and significantly poor a 9 months

• Background Sensitivity: performance is somewhat better on a "pure" 129/SvEv background

• no ataxia or other gross abnormalities up to 18 months of age

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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