Phenotypes associated with this allele

• Allele Symbol: Gata5^tm1Eno
• Allele Name: targeted mutation 1, Eric N Olson
• Allele ID: MGI:2386318
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gata5^tm1Eno/Gata5^tm1Eno	involves: 129S6/SvEvTac * C57BL/6	MGI:3640659

Genotype
MGI:3640659

hm1

• Allelic Composition: Gata5^tm1Eno/Gata5^tm1Eno
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal perineum morphology ( J:63036 )

♀

short perineum ( J:63036 )

♀ • anogenital distance is reduced in females

perineal fistula ( J:63036 )

♀ • commonly observed in females only

female preputial gland hypoplasia ( J:63036 )

♀ • sebaceous clitoral glands are hypoplastic

vaginal inflammation ( J:63036 )

♀ • exteriorized vaginal mucosa is frequently excoriated and inflamed

abnormal female reproductive system morphology ( J:63036 )

♀

absent clitoral bone ( J:63036 )

♀ • absence of os clitoris normally found in female mice

enlarged clitoris ( J:63036 )

♀ • much enlarged

abnormal vagina morphology ( J:63036 )

♀

abnormal vagina epithelium morphology ( J:63036 )

♀ • extends laterally over the perineum, replacing the haired skin

♀ • frequently excoriated and inflamed

abnormal vagina orifice morphology ( J:63036 )

♀ • abnormal shape

♀ • "gapes" open

reduced female fertility ( J:63036 )

♀ • due to vaginal tract obstructions

♀ • in contrast, male fertility is normal

renal/urinary system

urethritis ( J:63036 )

♀ • female urethra is lined by hyperplastic transitional epithelium which is often inflamed

abnormal female urethra morphology ( J:63036 )

♀ • distal urethra in females forms a trough along the surface of the vaginal wall rather than a distinct tube

abnormal urethra urothelium morphology ( J:63036 )

♀ • female urethra is lined by hyperplastic transitional epithelium which is often inflamed

digestive/alimentary system

abnormal perineum morphology ( J:63036 )

♀

short perineum ( J:63036 )

♀ • anogenital distance is reduced in females

perineal fistula ( J:63036 )

♀ • commonly observed in females only

immune system

urethritis ( J:63036 )

♀ • female urethra is lined by hyperplastic transitional epithelium which is often inflamed

vaginal inflammation ( J:63036 )

♀ • exteriorized vaginal mucosa is frequently excoriated and inflamed

endocrine/exocrine glands

female preputial gland hypoplasia ( J:63036 )

♀ • sebaceous clitoral glands are hypoplastic

skeleton

absent clitoral bone ( J:63036 )

♀ • absence of os clitoris normally found in female mice

integument

female preputial gland hypoplasia ( J:63036 )

♀ • sebaceous clitoral glands are hypoplastic