All Phenotypes Kat2b<tm1Roth> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Kat2b^tm1Roth
targeted mutation 1, Sharon Y Roth
MGI:2386280

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kat2b^tm1Roth/Kat2b^tm1Roth	involves: 129S7/SvEvBrd * C57BL/6J	MGI:3801421
cx2	Kat2a^tm1Roth/Kat2a^tm1Roth Kat2b^tm1Roth/Kat2b^tm1Roth	involves: 129S7/SvEvBrd * C57BL/6J	MGI:3801420

Allelic Composition	Kat2b^tm1Roth/Kat2b^tm1Roth
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kat2b^tm1Roth mutation (1 available); any Kat2b mutation (152 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:65002 )

• mice exhibit no obvious abnormal phenotype

Allelic Composition	Kat2a^tm1Roth/Kat2a^tm1Roth Kat2b^tm1Roth/Kat2b^tm1Roth
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kat2a^tm1Roth mutation (0 available); any Kat2a mutation (40 available)
Kat2b^tm1Roth mutation (1 available); any Kat2b mutation (152 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:65002 )

• mice die approximately at E7.5

embryo

embryonic growth retardation ( J:65002 )

abnormal embryonic tissue morphology ( J:65002 )

• at E6.5, mice are arrested at the egg cylinder stage with severely disorganized embryonic ectoderm and visceral endoderm

abnormal visceral yolk sac morphology ( J:65002 )

• some yolk sacs are filled with blood

growth/size/body

embryonic growth retardation ( J:65002 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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