Phenotypes associated with this allele

• Allele Symbol: Tyrobp^tm1Viv
• Allele Name: targeted mutation 1, Eric Vivier
• Allele ID: MGI:2386270
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tyrobp^tm1Viv/Tyrobp^tm1Viv	B6.129P2-Tyrobp^tm1Viv	MGI:3818482

Genotype
MGI:3818482

hm1

• Allelic Composition: Tyrobp^tm1Viv/Tyrobp^tm1Viv
• Genetic Background: B6.129P2-Tyrobp^tm1Viv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased susceptibility to Herpesvirales infection ( J:124749 )

• following infection with murine cytomegalovirus, viral titers are increased 30- to 40-fold in the liver and 2- to 5-fold in the spleen compared to in wild-type mice

• pre-treatment of murine cytomegalovirus infected mice with NK1.1 antibodies does not increase viral titer as in wild-type mice

• mice infected with murine cytomegalovirus exhibit increased severity of hepatitis compared to similarly treated wild-type mice that corresponds to elevated viral titers

• following infection with murine cytomegalovirus, mice exhibit 56% fewer IFN-gamma producing NK1.1+ cells and reduced INF-gamma production in the liver is decreased compared to similarly treated wild-type mice