Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4tm1Jml mutation
(0 available);
any
Gata4 mutation
(36 available)
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cardiovascular system
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• E8.5 embryos lacked ventral pericardial cavity and heart tube
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digestive/alimentary system
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• E10.5 embryos had defective gut tube formation
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embryo
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• defective ventral-dorsal folding
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• defective rostral-caudal folding
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• embryos smaller than wild-type and heterozygous littermates
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• defective closure of yolk sac at ventral surface of embryos
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growth/size/body
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• embryos smaller than wild-type and heterozygous littermates
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atoh8tm1.1Mlkn mutation
(0 available);
any
Atoh8 mutation
(7 available)
Gata4tm1Jml mutation
(0 available);
any
Gata4 mutation
(36 available)
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mortality/aging
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• small decrease in viability at P1 that becomes more pronounced at P14
• expected numbers are found at E17.5 indicating loss occurs between E17.5 and P1
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cardiovascular system
N |
• no phenotype in the heart as measured by echocardiography or histology at E17.5
• normal myocardial or contractile function
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respiratory system
N |
• despite expression in the lung mesenchyme, no gross defects in lung development are detected
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Allelic Composition |
Gata4tm1Jml/Gata4+ Gata5tm1Eem/Gata5+
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Genetic Background |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4tm1Jml mutation
(0 available);
any
Gata4 mutation
(36 available)
Gata5tm1Eem mutation
(0 available);
any
Gata5 mutation
(17 available)
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Ventriclular abnormalities in Gata4tm1Jml/Gata4+ Gata5tm1Eem/Gata5tm1Eem and Gata4tm1Jml/Gata4+ Gata5tm1Eem/Gata5+ mice
cardiovascular system
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• at E14.5, myocardial compact zone thickness is reduced 32% compared to in wild-type mice
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• as early as E12.5, the thickness of the ventricular compact myocardial layer is reduced 43% compared to in wild-type mice
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• some mice exhibit abnormal conoventricular septal defects (incomplete penetrance)
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muscle
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• at E14.5, myocardial compact zone thickness is reduced 32% compared to in wild-type mice
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• as early as E12.5, the thickness of the ventricular compact myocardial layer is reduced 43% compared to in wild-type mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4tm1Jml mutation
(0 available);
any
Gata4 mutation
(36 available)
Gata5tm1Eem mutation
(0 available);
any
Gata5 mutation
(17 available)
|
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Ventriclular abnormalities in Gata4tm1Jml/Gata4+ Gata5tm1Eem/Gata5tm1Eem and Gata4tm1Jml/Gata4+ Gata5tm1Eem/Gata5+ mice
mortality/aging
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• mice do not survive past E14.5 with no live mice found in newborn litters
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cardiovascular system
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• fine, abnormal trabecular structures
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• at E12.5, the thickness of the ventricular compact myocardial layer is reduced 61% compared to in wild-type mice
• at E14.5, the ventricular compact myocardial layer thickness is reduced 84% compared to in wild-type mice
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• conotruncal cushions are reduced in size and altered in location compared to in wild-type mice leading to abnormalities in ventriculoarterial positioning
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• endocardial cushions are hypoplastic at E12.5
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• mice exhibit a primum atrial septal defect unlike wild-type mice
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• mice exhibit a common atrioventricular canal and occasionally an unbalanced canal leading to a functionally univentricular heart
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• mice exhibit large inlet-type ventricular septal defect
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• mice exhibit moderately hypoplastic and anteriorly malaligned left ventricular outflow tracts
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• the right ventricular outflow tract is more posteriorly positioned than in wild-type mice
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• mice exhibit a thinning of the ventricular wall
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• at E14.5, mice exhibit systemic hemorrhage
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• proliferation of cells in the ventricular myocardium is reduced by 51% at E12.5 and 55% at E14.5 compared to in wild-type mice
• however, apoptosis rates are normal
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homeostasis/metabolism
muscle
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• fine, abnormal trabecular structures
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• at E12.5, the thickness of the ventricular compact myocardial layer is reduced 61% compared to in wild-type mice
• at E14.5, the ventricular compact myocardial layer thickness is reduced 84% compared to in wild-type mice
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• proliferation of cells in the ventricular myocardium is reduced by 51% at E12.5 and 55% at E14.5 compared to in wild-type mice
• however, apoptosis rates are normal
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cellular
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• proliferation of cells in the ventricular myocardium is reduced by 51% at E12.5 and 55% at E14.5 compared to in wild-type mice
• however, apoptosis rates are normal
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