Phenotypes associated with this allele

• Allele Symbol: Nppb^tm1Yog
• Allele Name: targeted mutation 1, Yoshihiro Ogawa
• Allele ID: MGI:2386215
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nppb^tm1Yog/Nppb^tm1Yog	either: 129X1/SvJ or (involves: 129 * C57BL/6J)	MGI:3522082

Genotype
MGI:3522082

hm1

• Allelic Composition: Nppb^tm1Yog/Nppb^tm1Yog
• Genetic Background: either: 129X1/SvJ or (involves: 129 * C57BL/6J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal myocardial fiber morphology ( J:61680 )

• ventricular myocytes exhibit supercontracted sarcomeres and disorganized myofibrils

abnormal heart ventricle morphology ( J:61680 )

• multifocal fibrotic lesions in subendocardial regions of ventricle in males aged 15 weeks or older

• aortic constriction to induce ventricular pressure overload caused increased size and number of fibrotic lesions

cardiac fibrosis ( J:61680 )

• multifocal fibrotic lesions in subendocardial regions of ventricle in males aged 15 weeks or older

• aortic constriction to induce ventricular pressure overload caused increased size and number of fibrotic lesions

muscle

abnormal myocardial fiber morphology ( J:61680 )

• ventricular myocytes exhibit supercontracted sarcomeres and disorganized myofibrils