Analysis Tools
mortality/aging
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• homozygotes tend to die with age
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immune system
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• number of lymphocytes in the periphery is about 2/3 of wild-type, although the number of red blood cells is normal
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• population of B220+mIgM+ B cells is reduced by 70 to 35% in the peripheral tissues such as the lymph node and spleen, however bone marrow shows normal levels
• population of B220hiIgM+ cells, but not B220loIgM+ cells is slightly decreased, suggesting that only recirculating B cells in the bone marrow are affected
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• spleen shows accumulation of a significant number of plasma cells and unusual lymphoblast-like cells carrying Mac1 antigen and cytoplasmic IgM
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• evident in mutants older than 3 months of age
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• increase in the mass of the white pulp, which contains large lymphoblast-like cells
• population of splenic B cells is reduced by half
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• splenic B cells survive longer time periods than those from wild-type
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• the proliferative response of splenic B cells to surface IgM cross-linking, CD40 ligand, and LPS is impaired
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• serum levels of all isotypes are higher than in wild-type in the absence of antigenic stimulation, indicating some abnormalities in class switching
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• 5-fold elevation in the absence of antigenic challenge
• IgA production is higher when challenged with DNP-KLH or TNP-LPS
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• 28-fold elevation in the absence of antigenic challenge
• IgM production is higher when challenged with DNP-KLH or TNP-LPS
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• Peyer's patches are smaller or undetectable
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• anti-dsDNA antibodies elevated, most of which are IgM
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• develop severe renal disease with hypercellularity, lobularity, and global sclerosis as age, an indication of autoimmune disease
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renal/urinary system
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• develop severe renal disease with hypercellularity, lobularity, and global sclerosis as age, an indication of autoimmune disease
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hematopoietic system
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• number of lymphocytes in the periphery is about 2/3 of wild-type, although the number of red blood cells is normal
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• population of B220+mIgM+ B cells is reduced by 70 to 35% in the peripheral tissues such as the lymph node and spleen, however bone marrow shows normal levels
• population of B220hiIgM+ cells, but not B220loIgM+ cells is slightly decreased, suggesting that only recirculating B cells in the bone marrow are affected
|
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• spleen shows accumulation of a significant number of plasma cells and unusual lymphoblast-like cells carrying Mac1 antigen and cytoplasmic IgM
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• evident in mutants older than 3 months of age
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• increase in the mass of the white pulp, which contains large lymphoblast-like cells
• population of splenic B cells is reduced by half
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• splenic B cells survive longer time periods than those from wild-type
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• the proliferative response of splenic B cells to surface IgM cross-linking, CD40 ligand, and LPS is impaired
|
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• serum levels of all isotypes are higher than in wild-type in the absence of antigenic stimulation, indicating some abnormalities in class switching
|
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• 5-fold elevation in the absence of antigenic challenge
• IgA production is higher when challenged with DNP-KLH or TNP-LPS
|
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• 28-fold elevation in the absence of antigenic challenge
• IgM production is higher when challenged with DNP-KLH or TNP-LPS
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cellular
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• the proliferative response of splenic B cells to surface IgM cross-linking, CD40 ligand, and LPS is impaired
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growth/size/body
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• evident in mutants older than 3 months of age
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