Analysis Tools
mortality/aging
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• heterozygous females developed until E19, some lethality earlier depending on extent of X-inactivation
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nervous system
exencephaly
(
J:53967
)
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craniofacial
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• neural tube is open from anterior extremity of cranial region to hindbrain
• abnormalities are evident by E9.5
• the maxilla and mandibular bones were underdeveloped and did not fuse at the midline
• 77% of female embryos have cephalic region abnormalities
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skeleton
|
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• neural tube is open from anterior extremity of cranial region to hindbrain
• abnormalities are evident by E9.5
• the maxilla and mandibular bones were underdeveloped and did not fuse at the midline
• 77% of female embryos have cephalic region abnormalities
|
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• abormal bending of limbs noted
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