All Phenotypes Piga<tm1Bsl> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Piga^tm1Bsl/Piga⁺ Tg(FES-cre)31Bsl/0	involves: 129S1/Sv * C57BL/6 * CBA/Ca	MGI:3814205
cn2	Piga^tm1Bsl/Y Tg(FES-cre)31Bsl/0	involves: 129S1/Sv * C57BL/6 * CBA/Ca	MGI:3814206
cn3	Piga^tm1Bsl/Piga⁺ Tg(EIIa-cre)C5379Lmgd/0	involves: 129S1/Sv * FVB/NJ	MGI:3814198

Allelic Composition	Piga^tm1Bsl/Piga⁺ Tg(FES-cre)31Bsl/0
Genetic Background	involves: 129S1/Sv * C57BL/6 * CBA/Ca

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Piga^tm1Bsl mutation (0 available); any Piga mutation (3 available)
Tg(FES-cre)31Bsl mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

weight loss ( J:71354 )

• developing around 12 months of age

behavior/neurological

weakness ( J:71354 )

• general muscular weakness after 12 months of age

decreased locomotor activity ( J:71354 )

• decreased overall activity after 12 months of age

neoplasm

increased hemangioma incidence ( J:71354 )

• sometimes seen in spleen and lymph nodes at 12 months of age

increased B cell derived lymphoma incidence ( J:71354 )

• sometimes seen in spleen and lymph nodes at 12 months of age

Allelic Composition	Piga^tm1Bsl/Y Tg(FES-cre)31Bsl/0
Genetic Background	involves: 129S1/Sv * C57BL/6 * CBA/Ca

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Piga^tm1Bsl mutation (0 available); any Piga mutation (3 available)
Tg(FES-cre)31Bsl mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

weight loss ( J:71354 )

• developing around 12 months of age

behavior/neurological

weakness ( J:71354 )

• general muscular weakness after 12 months of age

abnormal gait ( J:71354 )

• wide gait in males only, after 12 months of age

decreased locomotor activity ( J:71354 )

• decreased overall activity after 12 months of age

neoplasm

increased hemangioma incidence ( J:71354 )

• sometimes seen in spleen and lymph nodes at 12 months of age

increased B cell derived lymphoma incidence ( J:71354 )

• sometimes seen in spleen and lymph nodes at 12 months of age

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:75506 )

• increased perinatal lethality

hematopoietic system

abnormal definitive hematopoiesis ( J:75506 )

• high level of blood cells lacking glycosylphosphatidylinositol anchors

abnormal erythrocyte morphology ( J:75506 )

• level of RBC lacking glycosylphosphatidylinositol anchors highest at birth (up to 53%) and declining over 4 weeks to around 4%

reticulocytosis ( J:75506 )

• elevated numbers of reticulocytes

abnormal erythrocyte physiology ( J:75506 )

• RBC half life only 50% of normal

increased erythrocyte osmotic fragility ( J:75506 )

• increased susceptibility to lytic activity of activated complement

craniofacial

abnormal facial morphology ( J:56055 )

• orofacial abnormalities when cre recombination levels are highest

cleft palate ( J:56055 )

• when cre recombination levels are highest

behavior/neurological

abnormal suckling behavior ( J:56055 )

• unable to suckle when cre recombination levels are highest

digestive/alimentary system

cleft palate ( J:56055 )

• when cre recombination levels are highest

growth/size/body

abnormal facial morphology ( J:56055 )

• orofacial abnormalities when cre recombination levels are highest

cleft palate ( J:56055 )

• when cre recombination levels are highest

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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