Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vamp3tm1Jpes mutation
(1 available);
any
Vamp3 mutation
(17 available)
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hematopoietic system
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• rate of release of dense core granule release are slightly increased relative to wild-type
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homeostasis/metabolism
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vamp3tm1Jpes mutation
(1 available);
any
Vamp3 mutation
(17 available)
|
|
|
immune system
N |
• degranulation of mast cells is normal in these mice
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vamp3tm1Jpes mutation
(1 available);
any
Vamp3 mutation
(17 available)
|
|
|
nervous system
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• in hippocampal neurons from double knockout mice, frequency of miniEPSCs is ~8-fold lower than wild-type, but not different from Vamp2-single knockouts
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• double knockouts do not show a decrease in neurotransmitter release beyond that seen in Vamp2 single knockouts
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hematopoietic system
N |
• thrombin response curves and kinetics of release in platelets are not different from wild-type
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