All Phenotypes Vamp3<tm1Jpes> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Vamp3^tm1Jpes
targeted mutation 1, Jeffrey E Pessin
MGI:2385941

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Vamp3^tm1Jpes/Vamp3^tm1Jpes	involves: 129P2/OlaHsd * C57BL/6J	MGI:3803622
hm2	Vamp3^tm1Jpes/Vamp3^tm1Jpes	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3621969
hm3	Vamp3^tm1Jpes/Vamp3^tm1Jpes	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:2653846
cx4	Vamp2^tm1Sud/Vamp2^tm1Sud Vamp3^tm1Jpes/Vamp3^tm1Jpes	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	MGI:3639286
cx5	Vamp2^tm1Sud/Vamp2⁺ Vamp3^tm1Jpes/Vamp3^tm1Jpes	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:3803621

Allelic Composition	Vamp3^tm1Jpes/Vamp3^tm1Jpes
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vamp3^tm1Jpes mutation (1 available); any Vamp3 mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal platelet physiology ( J:121010 )

• rate of release of dense core granule release are slightly increased relative to wild-type

homeostasis/metabolism

abnormal platelet physiology ( J:121010 )

• rate of release of dense core granule release are slightly increased relative to wild-type

Allelic Composition	Vamp3^tm1Jpes/Vamp3^tm1Jpes
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vamp3^tm1Jpes mutation (1 available); any Vamp3 mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:131926 )

N	• degranulation of mast cells is normal in these mice

Allelic Composition	Vamp3^tm1Jpes/Vamp3^tm1Jpes
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vamp3^tm1Jpes mutation (1 available); any Vamp3 mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:67364 )

• no defect detected

Allelic Composition	Vamp2^tm1Sud/Vamp2^tm1Sud Vamp3^tm1Jpes/Vamp3^tm1Jpes
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vamp2^tm1Sud mutation (1 available); any Vamp2 mutation (18 available)
Vamp3^tm1Jpes mutation (1 available); any Vamp3 mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased miniature excitatory postsynaptic current frequency ( J:109985 )

• in hippocampal neurons from double knockout mice, frequency of miniEPSCs is ~8-fold lower than wild-type, but not different from Vamp2-single knockouts

abnormal neurotransmitter secretion ( J:109985 )

• double knockouts do not show a decrease in neurotransmitter release beyond that seen in Vamp2 single knockouts

Allelic Composition	Vamp2^tm1Sud/Vamp2⁺ Vamp3^tm1Jpes/Vamp3^tm1Jpes
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:121010 )

N	• thrombin response curves and kinetics of release in platelets are not different from wild-type

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