Phenotypes associated with this allele

• Allele Symbol: P2rx3^tm1Jwo
• Allele Name: targeted mutation 1, John N Wood
• Allele ID: MGI:2385840
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	P2rx3^tm1Jwo/P2rx3^tm1Jwo	either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * MF1)	MGI:3841782

Genotype
MGI:3841782

hm1

• Allelic Composition: P2rx3^tm1Jwo/P2rx3^tm1Jwo
• Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * MF1)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal single cell response ( J:65558 )

• fewer dorsal root ganglion neurons respond to ATP with an inward current and desensitization is lower

• only 1 of 20 ATP responding neurons also respond to alpha,beta,methyl ATP

• peak current in nodose ganglion neurons in response to ATP is somewhat lower than in controls and desensitization is slower

• alpha,beta,methyl ATP fails to evoke a response

behavior/neurological

abnormal touch/ nociception ( J:65558 )

• mechanically induced sensory responses are normal

abnormal chemical nociception ( J:65558 )

• formalin induced pain behavior is reduced

• hyperalgesia response to Freund's adjuvant but not to carrageenan

increased thermal nociceptive threshold ( J:65558 )

• very little thermal response in neurons until noxious temperatures are reached