Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mpotm1Lus mutation
(1 available);
any
Mpo mutation
(55 available)
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immune system
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• neutrophils exhibit reduced lysis of muscles cells that are superoxide dismutase treated, mechanically loaded muscle cells whereas lysis by wild-type neutrophils is increased
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muscle
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• following an unloading and reloading protocol, muscle fibers exhibit 52% less injury than in wild-type mice and membrane lysis is reduced
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homeostasis/metabolism
hematopoietic system
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• neutrophils exhibit reduced lysis of muscles cells that are superoxide dismutase treated, mechanically loaded muscle cells whereas lysis by wild-type neutrophils is increased
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mpotm1Lus mutation
(1 available);
any
Mpo mutation
(55 available)
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cardiovascular system
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• when bone marrow transplanted into irradiated Ldlrtm1Her homozygotes, mice fed a high fat diet develop 1.9-fold larger atherosclerotic lesions than in Ldlrtm1Her homozygotes transplanted with wild-type bone marrow
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mpotm1Lus mutation
(1 available);
any
Mpo mutation
(55 available)
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mortality/aging
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• following infection with Candida, 40% of mice die by day 20 compared to 100% survival of wild-type mice 65 days after infection
(J:67586)
• no mice are alive 5 days after cecal ligation and puncture (CLP) unlike wild-type mice that exhibit 63% survival after 5 days and 38% after 1 week
(J:126649)
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immune system
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• when bone marrow is transplanted into irradiated Ldlrtm1Her homozygotes, mice fed a high fat, high-cholesterol diet exhibit increased monocyte cells in atherosclerotic lesions compared to Ldlrtm1Her homozygotes transplanted with wild type bone marrow
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• neutrophils fail to produce hypochlorous acid and to chlorinate proteins in vivo
• in culture, neutrophils exhibit reduced killing of Candida and more ingested Candida germinate than when ingested by wild-type neutrophils
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• 90% of mice develop hind quarter paralysis following exposure to MOG35-55 peptide in complete Freunds adjuvant (CFA) with pertussis toxin compared to 33% of wild-type mice during 30 days of observation
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• asbestos-associated inflammation is delayed compared to in wild-type mice
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• following infection with Candida, 40% of mice die by day 20 compared to 100% survival of wild-type mice 65 days after infection
• unlike wild-type mice, following infection with Candida mice exhibit fungal infiltration of the kidneys
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• no mice are alive 5 days after cecal ligation and puncture (CLP) unlike wild-type mice that exhibit 63% survival after 5 days and 38% after 1 week
• however, cellular response to sepsis is normal
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cardiovascular system
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• when bone marrow transplanted into irradiated Ldlrtm1Her homozygotes, mice fed a high fat, high-cholesterol diet develop 50% larger atherosclerotic lesions than in Ldlrtm1Her homozygotes transplanted with wild-type bone marrow
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homeostasis/metabolism
hematopoietic system
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• when bone marrow is transplanted into irradiated Ldlrtm1Her homozygotes, mice fed a high fat, high-cholesterol diet exhibit increased monocyte cells in atherosclerotic lesions compared to Ldlrtm1Her homozygotes transplanted with wild type bone marrow
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• neutrophils fail to produce hypochlorous acid and to chlorinate proteins in vivo
• in culture, neutrophils exhibit reduced killing of Candida and more ingested Candida germinate than when ingested by wild-type neutrophils
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Analysis Tools