Analysis Tools
immune system
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• spleens have increased number of dendritic cells than controls 3 days after infection with L. monocytogenes than in controls
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• natural killer cells have increased numbers in the spleen controls 3 days after infection with L. monocytogenes than in controls
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• macrophages have increased numbers in the spleen 2 days after infection with L. monocytogenes than in controls
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• very little IFN-gamma is detected in sera after of L. monocytogenes infection compared to controls that have relatively high levels of IFN-gamma 24 to 48 hours after L. monocytogenes
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• no IL-18 is detectable in the sera of mice
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• slightly decreased serum levels of IL-6 are found 2- to 3- days after L. monocytogenes infection, likely reflecting the lower titers of bacteria found at these timepoints
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• splenocytes from mice infected with L. monocytogenes produce about half the amount of IFN-gamma that controls do when exposed to L. monocytogenes antigens in vitro
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• slightly decreased serum levels of TNF are found 2- to 3- days after L. monocytogenes infection, likely reflecting the lower titers of bacteria found at these timepoints
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• mice are less susceptible to infection by the intracellular bacteria Listeria monocytogenes
• the number of viable bacteria isolated from the liver and spleens is 500 times lower than controls 3 days after injection with either medium (0.5-fold of the LD50) or high (2.5-fold of the LD50) dose of L. monocytogenes
• the frequency of neutrophilic microfoci is about five times lower in liver sections from infected mutant mice compared to controls
• the first differences in bacterial titers are noticeable 48 hours after infection with 5 to 30 times lower titers in the liver and spleen
• mice have reduced apoptosis of the white pulp that occurs 24- to 72- hours after infection
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homeostasis/metabolism
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• NO production by splenocytes is decreased 3 days after infection with L. monocytogenes, likely reflecting the lower titers of bacteria found at these timepoints
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• very little IFN-gamma is detected in sera after of L. monocytogenes infection compared to controls that have relatively high levels of IFN-gamma 24 to 48 hours after L. monocytogenes
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• no IL-18 is detectable in the sera of mice
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• slightly decreased serum levels of IL-6 are found 2- to 3- days after L. monocytogenes infection, likely reflecting the lower titers of bacteria found at these timepoints
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hematopoietic system
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• spleens have increased number of dendritic cells than controls 3 days after infection with L. monocytogenes than in controls
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• natural killer cells have increased numbers in the spleen controls 3 days after infection with L. monocytogenes than in controls
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• macrophages have increased numbers in the spleen 2 days after infection with L. monocytogenes than in controls
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