All Phenotypes Per3<tm1Drw> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Per3^tm1Drw
targeted mutation 1, David R Weaver
MGI:2385797

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Per3^tm1Drw/Per3^tm1Drw	involves: 129S4/SvJae	MGI:3029171
hm2	Per3^tm1Drw/Per3^tm1Drw	involves: 129S4/SvJae * C57BL/6	MGI:5751479
cx3	Per1^tm1Drw/Per1^tm1Drw Per3^tm1Drw/Per3^tm1Drw	involves: 129S4/SvJae	MGI:3852064
cx4	Mfrp^rdx/Mfrp^rdx Per3^tm1Drw/Per3^tm1Drw	involves: 129S4/SvJae	MGI:5312659
cx5	Per2^tm1Drw/Per2^tm1Drw Per3^tm1Drw/Per3^tm1Drw	involves: 129/Sv * 129S4/SvJae	MGI:3852067

Allelic Composition	Per3^tm1Drw/Per3^tm1Drw
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Per3^tm1Drw mutation (2 available); any Per3 mutation (47 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

shortened circadian behavior period ( J:63933 )

• homozygous male mice exhibited a shorter free running period when exposed to constant light; a subset of these mice continued to exhibit a shortening of period length progressive with time

abnormal sleep pattern ( J:95746 )

• during the 12-hour recovery after 6 hours of prolonged waking, mice exhibit less waking than similarly treated wild-type mice

nervous system

abnormal brain wave pattern ( J:95746 )

• recovery after 6 hours of prolonged waking, mice exhibit an increase in delta power lasting the first 6 hours of recovery sleep period compared with wild-type mice in which it lasts 3 hours

Allelic Composition	Per3^tm1Drw/Per3^tm1Drw
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Per3^tm1Drw mutation (2 available); any Per3 mutation (47 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavioral despair ( J:229233 )

• mice exhibit an increased duration of immobility in tail suspension test under 12 hr light/12 hr dark; duration of immobility is intensified under 4 hr light/20 hr dark

• mice exhibit an increased duration of immobility in forced swim test under 4 hr light/20 hr dark, but not under 12 hr light/12 hr dark

• treatment with anti-depressant imipramine decreases duration of immobility

• mice ingest less sucrose solution than controls

Allelic Composition	Per1^tm1Drw/Per1^tm1Drw Per3^tm1Drw/Per3^tm1Drw
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Per1^tm1Drw mutation (2 available); any Per1 mutation (62 available)
Per3^tm1Drw mutation (2 available); any Per3 mutation (47 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

arrhythmic circadian behavior persistence ( J:69626 )

• as in Per1^tm1Drw homozygotes

Allelic Composition	Mfrp^rdx/Mfrp^rdx Per3^tm1Drw/Per3^tm1Drw
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mfrp^rdx mutation (0 available); any Mfrp mutation (27 available)
Per3^tm1Drw mutation (2 available); any Per3 mutation (47 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

retina degeneration ( J:181596 )

• limited to the outer layers of the retina and uniform form the center to the periphery

abnormal eye electrophysiology ( J:181596 )

• near complete loss of a-wave

Allelic Composition	Per2^tm1Drw/Per2^tm1Drw Per3^tm1Drw/Per3^tm1Drw
Genetic Background	involves: 129/Sv * 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Per2^tm1Drw mutation (2 available); any Per2 mutation (71 available)
Per3^tm1Drw mutation (2 available); any Per3 mutation (47 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

arrhythmic circadian behavior persistence ( J:69626 )

• as in Per2^tm1Drw homozygotes

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