Phenotypes associated with this allele

• Allele Symbol: Ltb4r1^tm1Adl
• Allele Name: targeted mutation 1, Andrew D Luster
• Allele ID: MGI:2385786
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ltb4r1^tm1Adl/Ltb4r1^tm1Adl	involves: 129S4/SvJae * C57BL/6	MGI:3811007
cx2	Apoe^tm1Bres/Apoe^tm1Bres Ltb4r1^tm1Adl/Ltb4r1^tm1Adl	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	MGI:3811013

Genotype
MGI:3811007

hm1

• Allelic Composition: Ltb4r1^tm1Adl/Ltb4r1^tm1Adl
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal leukocyte migration ( J:63873 )

• after 96 hours, leukocyte recruitment in thioglycollate-induced peritonitis is 61% of wild-type

abnormal leukocyte adhesion ( J:63873 )

• LTB4 fails to decrease rolling of leukocytes as in wild-type mice

impaired eosinophil recruitment ( J:63873 )

• after 48 hours, eosinophil recruitment in thioglycollate-induced peritonitis is 33% of wild-type

abnormal neutrophil physiology ( J:63873 )

• thioglycollate-elicited peritoneal neutrophils and macrophages fail to exhibit calcium fluxes unlike in wild-type controls

• however, calcium fluxes in response to chemokines is normal

impaired neutrophil chemotaxis ( J:63873 )

• neutrophils fail to exhibit chemotaxis in response to LTB4 unlike wild-type cells

abnormal macrophage physiology ( J:63873 )

• thioglycollate-elicited peritoneal neutrophils and macrophages fail to exhibit calcium fluxes unlike in wild-type controls

• however, calcium fluxes in response to chemokines is normal

cellular

impaired neutrophil chemotaxis ( J:63873 )

• neutrophils fail to exhibit chemotaxis in response to LTB4 unlike wild-type cells

abnormal leukocyte migration ( J:63873 )

• after 96 hours, leukocyte recruitment in thioglycollate-induced peritonitis is 61% of wild-type

abnormal leukocyte adhesion ( J:63873 )

• LTB4 fails to decrease rolling of leukocytes as in wild-type mice

hematopoietic system

abnormal leukocyte migration ( J:63873 )

• after 96 hours, leukocyte recruitment in thioglycollate-induced peritonitis is 61% of wild-type

abnormal leukocyte adhesion ( J:63873 )

• LTB4 fails to decrease rolling of leukocytes as in wild-type mice

impaired eosinophil recruitment ( J:63873 )

• after 48 hours, eosinophil recruitment in thioglycollate-induced peritonitis is 33% of wild-type

abnormal neutrophil physiology ( J:63873 )

• thioglycollate-elicited peritoneal neutrophils and macrophages fail to exhibit calcium fluxes unlike in wild-type controls

• however, calcium fluxes in response to chemokines is normal

impaired neutrophil chemotaxis ( J:63873 )

• neutrophils fail to exhibit chemotaxis in response to LTB4 unlike wild-type cells

abnormal macrophage physiology ( J:63873 )

• thioglycollate-elicited peritoneal neutrophils and macrophages fail to exhibit calcium fluxes unlike in wild-type controls

• however, calcium fluxes in response to chemokines is normal

Genotype
MGI:3811013

cx2

• Allelic Composition: Apoe^tm1Bres/Apoe^tm1Bres; Ltb4r1^tm1Adl/Ltb4r1^tm1Adl
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

cardiovascular system

decreased susceptibility to atherosclerosis ( J:117166 )

• mice exhibit a 55% reduced plaque burden compared to in Apoe^tm1Bres homozygotes

• when fed a Western diet, mice exhibit reduced plaque development, intimal area, and monocyte and T cell accumulation compared to in Apoe^tm1Bres homozygotes

• when fed a western diet, mice exhibit a 42.6% reduction in smooth muscle cells in the media and fibromuscular caps of lesions compared to in Apoe^tm1Bres homozygotes