Phenotypes associated with this allele

• Allele Symbol: Ltb4r1^tm1Bodd
• Allele Name: targeted mutation 1, Bodduluri Haribabu
• Allele ID: MGI:2385781
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ltb4r1^tm1Bodd/Ltb4r1^tm1Bodd	either: (involves: 129S4/SvJaeSor * BALB/c ) or (involves: 129S4/SvJaeSor * C57BL/6)	MGI:4822411
hm2	Ltb4r1^tm1Bodd/Ltb4r1^tm1Bodd	involves: 129S4/SvJaeSor	MGI:3811002
hm3	Ltb4r1^tm1Bodd/Ltb4r1^tm1Bodd	involves: 129S4/SvJaeSor * C57BL/6	MGI:3624534

Genotype
MGI:4822411

hm1

• Allelic Composition: Ltb4r1^tm1Bodd/Ltb4r1^tm1Bodd
• Genetic Background: either: (involves: 129S4/SvJaeSor * BALB/c ) or (involves: 129S4/SvJaeSor * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

impaired neutrophil chemotaxis ( J:163271 )

• in response to Ltb4

decreased susceptibility to induced arthritis ( J:163271 )

• in a K/BxN serum transfer model, mice do not exhibit any inflammation or bone erosion in joints unlike similarly treated wild-type mice

skeleton

decreased susceptibility to induced arthritis ( J:163271 )

• in a K/BxN serum transfer model, mice do not exhibit any inflammation or bone erosion in joints unlike similarly treated wild-type mice

cellular

impaired neutrophil chemotaxis ( J:163271 )

• in response to Ltb4

hematopoietic system

impaired neutrophil chemotaxis ( J:163271 )

• in response to Ltb4

Genotype
MGI:3811002

hm2

• Allelic Composition: Ltb4r1^tm1Bodd/Ltb4r1^tm1Bodd
• Genetic Background: involves: 129S4/SvJaeSor

immune system

decreased susceptibility to induced arthritis ( J:131779 )

• following treatment with collagen to induce arthritis, mice exhibit no evidence of immune infiltration, pannus formation or fibrillation of the cartilage unlike in similarly treated wild-type mice

• however, mice do produce antibodies against collagen type II

decreased synovial pannus formation ( J:131779 )

• following treatment with collagen to induce arthritis, mice exhibit no evidence of pannus formation

skeleton

decreased susceptibility to induced arthritis ( J:131779 )

• following treatment with collagen to induce arthritis, mice exhibit no evidence of immune infiltration, pannus formation or fibrillation of the cartilage unlike in similarly treated wild-type mice

• however, mice do produce antibodies against collagen type II

decreased synovial pannus formation ( J:131779 )

• following treatment with collagen to induce arthritis, mice exhibit no evidence of pannus formation

Genotype
MGI:3624534

hm3

• Allelic Composition: Ltb4r1^tm1Bodd/Ltb4r1^tm1Bodd
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

immune system

decreased susceptibility to autoimmune disorder ( J:108446 )

• upon adoptive transfer of IRBP1-20-specific T cells from wild-type B6 donors to wild-type and Ltbr4-deficient recipients, wild-type mice develop chronic and severe uveitis, whereas mutant recipients show only mild and transient clinical disease

• adoptive transfer of IRBP1-20-specific Ltbr4-deficient mice to B6 recipients results in moderate uveitis, while transfer to Ltbr4-deficient recipients do not develop disease