Phenotypes associated with this allele

• Allele Symbol: Lhx1^tm3.1Bhr
• Allele Name: targeted mutation 3.1, Richard R Behringer
• Allele ID: MGI:2385728
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lhx1^tm3.1Bhr/Lhx1^tm3.1Bhr	involves: 129S7/SvEvBrd * C57BL/6	MGI:3783647

Genotype
MGI:3783647

hm1

• Allelic Composition: Lhx1^tm3.1Bhr/Lhx1^tm3.1Bhr
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:63192 )

• mutants die at 10 days post-coitum (dpc)

embryo

abnormal neural tube morphology ( J:63192 )

• mutant embryos lack tissue anterior to rhombomere 3 at 9.5 dpc

embryonic-extraembryonic boundary constriction ( J:63192 )

• during gastrulation, embryos display a constriction of variable severity

abnormal primitive streak elongation ( J:63192 )

• length of primitive streak is shortened relative to wild-type

nervous system

abnormal neural tube morphology ( J:63192 )

• mutant embryos lack tissue anterior to rhombomere 3 at 9.5 dpc

absent midbrain ( J:63192 )

• embryos lack midbrain tissue at 9.5 dpc

absent forebrain ( J:63192 )

• embryos lack forebrain tissue at 9.5 dpc

growth/size/body

abnormal anterior head development ( J:63192 )

• abnormalities in anterior head region are detectable at 8 dpc; defects appear to be completely penetrant

• mutants show anterior head truncations at boundary of rhombomeres 2 and 3 of hindbrain