Phenotypes associated with this allele

• Allele Symbol: Hoxa2^tm1Fmr
• Allele Name: targeted mutation 1, Filippo M Rijli
• Allele ID: MGI:2385689
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hoxa2^tm1Fmr/Hoxa2^tm1Fmr	involves: 129/Sv * C57BL/6	MGI:3773620
ht2	Hoxa2^tm1Fmr/Hoxa2^+	involves: 129/Sv * C57BL/6	MGI:3773618

Genotype
MGI:3773620

hm1

• Allelic Composition: Hoxa2^tm1Fmr/Hoxa2^tm1Fmr
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality at weaning, complete penetrance ( J:80131 )

• mice die at three weeks of age

craniofacial

abnormal styloid process morphology ( J:80131 )

• at E18.5, some mice exhibit unilateral abnormalities in the styloid process

abnormal hyoid bone lesser horn morphology ( J:80131 )

• at E18.5, some mice exhibit unilateral abnormalities in the lesser horns of the hyoid bone

abnormal stapes morphology ( J:80131 )

• at E18.5, some mice exhibit unilateral abnormalities in the stapes

growth/size/body

abnormal hyoid bone lesser horn morphology ( J:80131 )

• at E18.5, some mice exhibit unilateral abnormalities in the lesser horns of the hyoid bone

postnatal growth retardation ( J:80131 )

hearing/vestibular/ear

abnormal stapes morphology ( J:80131 )

• at E18.5, some mice exhibit unilateral abnormalities in the stapes

nervous system

abnormal rhombomere 2 morphology ( J:80131 )

• segmentation and patterning of rhombomere 2 is disrupted as determined by marker expression patterns

• however, patterning of rhombomere 3 is normal

skeleton

abnormal styloid process morphology ( J:80131 )

• at E18.5, some mice exhibit unilateral abnormalities in the styloid process

abnormal hyoid bone lesser horn morphology ( J:80131 )

• at E18.5, some mice exhibit unilateral abnormalities in the lesser horns of the hyoid bone

abnormal stapes morphology ( J:80131 )

• at E18.5, some mice exhibit unilateral abnormalities in the stapes

embryo

abnormal rhombomere 2 morphology ( J:80131 )

• segmentation and patterning of rhombomere 2 is disrupted as determined by marker expression patterns

• however, patterning of rhombomere 3 is normal

Genotype
MGI:3773618

ht2

• Allelic Composition: Hoxa2^tm1Fmr/Hoxa2⁺
• Genetic Background: involves: 129/Sv * C57BL/6

normal phenotype

no abnormal phenotype detected ( J:80131 )

• mice display no abnormal phenotype