Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcl13tm1Cys mutation
(1 available);
any
Cxcl13 mutation
(19 available)
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immune system
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• germinal center (GC) B cells migrate more slowly in culture than wild-type GC B cells; cells show a slower velocity and less mean displacement over time compared to wild-type cells
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hematopoietic system
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• germinal center (GC) B cells migrate more slowly in culture than wild-type GC B cells; cells show a slower velocity and less mean displacement over time compared to wild-type cells
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcl13tm1Cys mutation
(1 available);
any
Cxcl13 mutation
(19 available)
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immune system
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• B cells fail to organize into polarized follicular clusters and appear as a ring of cells at the perimeter of T-cell areas
• boundary between B-cell rich areas and T zones are often poorly demarcated, with increased numbers of B cells and T cells in reciprocal areas
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• germinal centers form in spleen after immunization with T-cell dependent antigen, however they are misplaced and smaller
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• spleen shows a thickened ring of IgMhiIgDlo marginal zone B cells and the boundary between the B cells in this area and the inner ring of B cells is disrupted, with increased numbers of IgMhiIgDlo cells in the outer marginal zone
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• impaired trafficking of B cells to lymphoid follicles
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• absence of primary follicular dendritic cells in spleen and lymph nodes
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• Peyer's patches that are observed lack the characteristic multi-domed structure
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• Peyer's patches that are observed are small
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• germinal centers form in lymph nodes after immunization with T-cell dependent antigen, however they are misplaced and smaller
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• most mice lack inguinal, iliac, sacral, brachial, and axillary lymph nodes
• however, a full set of mesenteric lymph nodes is observed
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hematopoietic system
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• B cells fail to organize into polarized follicular clusters and appear as a ring of cells at the perimeter of T-cell areas
• boundary between B-cell rich areas and T zones are often poorly demarcated, with increased numbers of B cells and T cells in reciprocal areas
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• germinal centers form in spleen after immunization with T-cell dependent antigen, however they are misplaced and smaller
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• spleen shows a thickened ring of IgMhiIgDlo marginal zone B cells and the boundary between the B cells in this area and the inner ring of B cells is disrupted, with increased numbers of IgMhiIgDlo cells in the outer marginal zone
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• impaired trafficking of B cells to lymphoid follicles
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Analysis Tools