Phenotypes associated with this allele

• Allele Symbol: Foxb1^tm1Lby
• Allele Name: targeted mutation 1, Patricia A Labosky
• Allele ID: MGI:2384415
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Foxb1^tm1Lby/Foxb1^tm1Lby	129S6/SvEvTac-Foxb1^tm1Lby	MGI:3843799
hm2	Foxb1^tm1Lby/Foxb1^tm1Lby	B6.129S6-Foxb1^tm1Lby	MGI:3843796
hm3	Foxb1^tm1Lby/Foxb1^tm1Lby	involves: 129S6/SvEvTac * Black Swiss	MGI:3843785
hm4	Foxb1^tm1Lby/Foxb1^tm1Lby	involves: 129S6/SvEvTac * CD-1	MGI:3843792

Genotype
MGI:3843799

hm1

• Allelic Composition: Foxb1^tm1Lby/Foxb1^tm1Lby
• Genetic Background: 129S6/SvEvTac-Foxb1^tm1Lby

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

galactostasis ( J:67882 )

♀ • Background Sensitivity: females fail to eject milk to feed their young

♀ • lactation can often be restored by oxytocin injection

integument

galactostasis ( J:67882 )

♀ • Background Sensitivity: females fail to eject milk to feed their young

♀ • lactation can often be restored by oxytocin injection

behavior/neurological

galactostasis ( J:67882 )

♀ • Background Sensitivity: females fail to eject milk to feed their young

♀ • lactation can often be restored by oxytocin injection

Genotype
MGI:3843796

hm2

• Allelic Composition: Foxb1^tm1Lby/Foxb1^tm1Lby
• Genetic Background: B6.129S6-Foxb1^tm1Lby

endocrine/exocrine glands

galactostasis ( J:67882 )

♀ • Background Sensitivity: females fail to eject milk to feed their young

♀ • lactation can often be restored by oxytocin injection

abnormal mammary gland morphology ( J:67882 )

♀ • Background Sensitivity: more proportional to body size

abnormal mammary gland epithelium morphology ( J:67882 )

♀ • no lipid in epithelial cells

abnormal mammary gland lobule morphology ( J:67882 )

♀ • less lobuloalveolar development

♀ • long regions of ducts lack lobules

abnormal mammary gland alveolus morphology ( J:67882 )

♀ • fewer alveoli are present and these have smaller lumens

♀ • terminal end buds randomly oriented rather than oriented distally as in controls

nervous system

decreased inferior colliculus size ( J:67882 )

• Background Sensitivity: completely covered by the cerebellum

abnormal mammillary body morphology ( J:67882 )

• reduced in size at 7 days of age

• mammillothalamic tract axons defasiculated and diffuse starting around 5 days of age

integument

galactostasis ( J:67882 )

♀ • Background Sensitivity: females fail to eject milk to feed their young

♀ • lactation can often be restored by oxytocin injection

abnormal mammary gland morphology ( J:67882 )

♀ • Background Sensitivity: more proportional to body size

abnormal mammary gland epithelium morphology ( J:67882 )

♀ • no lipid in epithelial cells

abnormal mammary gland lobule morphology ( J:67882 )

♀ • less lobuloalveolar development

♀ • long regions of ducts lack lobules

abnormal mammary gland alveolus morphology ( J:67882 )

♀ • fewer alveoli are present and these have smaller lumens

♀ • terminal end buds randomly oriented rather than oriented distally as in controls

behavior/neurological

galactostasis ( J:67882 )

♀ • Background Sensitivity: females fail to eject milk to feed their young

♀ • lactation can often be restored by oxytocin injection

Genotype
MGI:3843785

hm3

• Allelic Composition: Foxb1^tm1Lby/Foxb1^tm1Lby
• Genetic Background: involves: 129S6/SvEvTac * Black Swiss

behavior/neurological

behavior/neurological phenotype ( J:67882 )

N • Background Sensitivity: normal nursing behavior

endocrine/exocrine glands

abnormal mammary gland morphology ( J:67882 )

♀ • Background Sensitivity: larger than expected in relation to body size at 3 and 6 weeks of age

nervous system

decreased inferior colliculus size ( J:67882 )

• Background Sensitivity: smaller and displaced laterally in newborns , 3 and 6 week old mice

abnormal mammillary body morphology ( J:67882 )

• reduced in size at 7 days of age

• mammillothalamic tract axons defasiculated and diffuse starting around 5 days of age

integument

abnormal mammary gland morphology ( J:67882 )

♀ • Background Sensitivity: larger than expected in relation to body size at 3 and 6 weeks of age

Genotype
MGI:3843792

hm4

• Allelic Composition: Foxb1^tm1Lby/Foxb1^tm1Lby
• Genetic Background: involves: 129S6/SvEvTac * CD-1

behavior/neurological

behavior/neurological phenotype ( J:67882 )

N • Background Sensitivity: normal nursing behavior

nervous system

nervous system phenotype ( J:67882 )

N • Background Sensitivity: inferior colliculi are normal