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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gli3TgBR
transgenic insertion
MGI:2183948
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gli3TgBR/Gli3TgBR involves: C57BL/6J MGI:2668564
ht2
 		Gli3TgBR/Gli3+ involves: C57BL/6J MGI:2668574
ht3
 		Gli3TgBR/Gli3Xt involves: 101/H * C3H/HeH * C57BL/6J * CBA/H MGI:4415145
cx4
 		Gli3TgBR/Gli3+
ScribCrc/ScribCrc 		involves: C57BL/6J * NMRI MGI:4415141


Genotype
MGI:2668564
hm1
Allelic
Composition		 Gli3TgBR/Gli3TgBR
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3TgBR mutation (0 available); any Gli3 mutation (80 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

craniofacial
abnormal craniofacial morphology ( J:77245 )
• craniofacial malformation

limbs/digits/tail
abnormal limb morphology ( J:77245 )
• abnormal limb orientation
polydactyly ( J:77245 )
• severe, with greater number of extra digits than heterozygotes

respiratory system
respiratory distress ( J:77245 )
• at birth

skeleton
abnormal skeleton morphology ( J:77245 )
• multiple skeletal malformations

nervous system
exencephaly ( J:77245 )
• occasional
absent optic nerve ( J:77245 )
• no optic nerve is detected by DiI forward filling of the retina

growth/size/body
herniated abdominal wall ( J:77245 )
• occasional extrusion of abdominal contents

vision/eye
absent optic nerve ( J:77245 )
• no optic nerve is detected by DiI forward filling of the retina
microphthalmia ( J:77245 )
• small or absent eyes
anophthalmia ( J:77245 )
• small or absent eyes




Genotype
MGI:2668574
ht2
Allelic
Composition		 Gli3TgBR/Gli3+
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3TgBR mutation (0 available); any Gli3 mutation (80 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
preaxial polydactyly ( J:77245 )
• 100% of mutants exhibit preaxial polydactyly

nervous system
hydrocephaly ( J:77245 )
• hydrocephaly is noted as occasional




Genotype
MGI:4415145
ht3
Allelic
Composition		 Gli3TgBR/Gli3Xt
Genetic
Background		 involves: 101/H * C3H/HeH * C57BL/6J * CBA/H
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3TgBR mutation (0 available); any Gli3 mutation (80 available)
Gli3Xt mutation (1 available); any Gli3 mutation (80 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
polydactyly ( J:77245 )
• severe polydactyly (10 toes)

skeleton
abnormal skeleton morphology ( J:77245 )
• 1 of 5 mutants exhibits skeletal abnormalities




Genotype
MGI:4415141
cx4
Allelic
Composition		 Gli3TgBR/Gli3+
ScribCrc/ScribCrc
Genetic
Background		 involves: C57BL/6J * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3TgBR mutation (0 available); any Gli3 mutation (80 available)
ScribCrc mutation (2 available); any Scrib mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal innervation ( J:77245 )
• retinal axons project in circuitous, intersecting patterns across the retina before reaching the optic nerve head instead of a direct trajectory from their cell of origin toward the optic disk




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory