Analysis Tools
normal phenotype
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• embryos and adults appeared grossly normal; animals are viable and fertile
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Allele Symbol Allele Name Allele ID |
Crabp1tm1Ipc targeted mutation 1, Pierre Chambon MGI:2183739 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• embryos and adults appeared grossly normal; animals are viable and fertile
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• ~9% of double homozygotes die before 6 weeks of age
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• at P0-P42, 83% of double homozygotes show a forelimb outgrowth on the post-axial side of digit 5, either unilaterally (27%) or bilaterally (52%)
• this pots-axial digit outgrowth is of variable size and is also observed on all four limbs at a low frequency (4%)
• in severe cases, the digit rudiment bones are always floating
• in addition, 13% of double homozygotes display a pre-axial digit outgrowth in their hindlimbs, consisting of two bones not fully separated by a joint
• retinoic acid (RA) excess treatment in utero fails to increase the frequency of digit outgrowth, indicating normal sensitivity of double mutant embryos to RA excess
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| N |
• contrary to expectation, E18.5 double homozygotes show normal cochlear morphology with no structural changes at the level of the organ of Corti relative to wild-type mice
• in addition, double homozygotes show no significant differences in ABR thresholds and latencies or DPOAEs relative to wild-type mice, indicating normal auditory function
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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