Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sftpa1tm1Kor mutation
(1 available);
any
Sftpa1 mutation
(20 available)
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respiratory system
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• following infection with mycoplasma, the numbers of large surfactant aggregates is decreased and higher protein to lipid ratios are present in the bronchoalveolar lavage fluid compared to similarly infected wild-type mice
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sftpa1tm1Kor mutation
(1 available);
any
Sftpa1 mutation
(20 available)
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respiratory system
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• LPS-induced injury increases the number of alveolar resident cells compared to in similarly treated wild-type mice
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• LPS-induced injury decreases surfactant clearance 40% compared to in similarly treated wild-type mice
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homeostasis/metabolism
immune system
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N |
• mice exhibit a normal inflammatory response following infection with Cryptococcus neoformans
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• LPS-induced injury increases the number of alveolar resident cells compared to in similarly treated wild-type mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sftpa1tm1Kor mutation
(1 available);
any
Sftpa1 mutation
(20 available)
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mortality/aging
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• all mice born in a corn dust environment (resulting in exposure to various bacteria) die within 48 hours
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immune system
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• mice born in a corn dust environment exhibit gastrointestinal abnormalities and high bacteria count in peritoneal fluid unlike wild-type mice
• all mice born in a corn dust environment (resulting in exposure to various bacteria) die within 48 hours
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sftpa1tm1Kor mutation
(1 available);
any
Sftpa1 mutation
(20 available)
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immune system
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N |
• mice do not exhibit any altered lung inflammation
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• lung infiltrates are observed 6 hours after exposure to group B streptococcus (GBS) compared to in similarly treated wild-type mice that show infiltrate after 24 hours
• at 48 hours post-infection with GBS, inflammation persists and is more severe than in similarly treated wild-type mice
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• lung infiltrates are observed 6 hours after exposure to group B streptococcus (GBS) compared to in similarly treated wild-type mice that show infiltrate after 24 hours
(J:110382)
• at 48 hours post-infection with GBS, inflammation persists and is more severe than in similarly treated wild-type mice
mice exhibit reduced bacterial clearance compared to wild-type mice
(J:110382)
• mice exhibit increased systemic infection with GBS compared to wild-type mice with increased splenic burden
(J:110382)
• GBS associated with alveolar macrophages is decreased compared to in wild-type mice
(J:110382)
• mice exhibit increased susceptibility to infection with Pneumocystis carinii compared to wild-type mice
(J:120552)
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respiratory system
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N |
• mice do not exhibit any altered lung structure, alveolar phospholipids pool size or composition, or lung inflammation
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• lung infiltrates are observed 6 hours after exposure to group B streptococcus (GBS) compared to in similarly treated wild-type mice that show infiltrate after 24 hours
• at 48 hours post-infection with GBS, inflammation persists and is more severe than in similarly treated wild-type mice
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• surfactant exhibits decreased minimum surface tension and increased sensitivity to plasma inactivation compared to wild-type surfactant
• mice exhibit fewer large aggregates of surfactant compared to in wild-type mice
• the number of large surfactant aggregates following exposure to NMU (N-nitroso-N-methylurea) is decreased compared to in similarly treated wild-type mice
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Analysis Tools