Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation
(33 available);
any
Apoe mutation
(145 available)
Tg(APPV717I)1130Kha mutation
(0 available)
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mortality/aging
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• absence of Apoe does not modify or improve mouse survival relative to Tg(APPV717I)1130Kha mice expressing Apoe; significant mortality before 150 days of age is observed
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation
(33 available);
any
Apoe mutation
(145 available)
Tg(APPV717I)1130Kha mutation
(0 available)
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mortality/aging
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• absence of Apoe does not modify or improve mouse survival relative to Tg(APPV717I)1130Kha mice expressing Apoe; significant mortality before 150 days of age is observed
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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mortality/aging
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• 1/7 animals died prior to 170 days
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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mortality/aging
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• mice die sooner than Tg(APPV717I)1130Kha single transgenics
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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mortality/aging
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• Background Sensitivity: mice die at least as early as mice on FVB/N inbred background
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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mortality/aging
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N |
• Background Sensitivity: all mice remained alive for up to 407 days
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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mortality/aging
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• Background Sensitivity: mice die at least as early as mice on FVB/N inbred background
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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mortality/aging
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• Background Sensitivity: 100% of mice die prematurely, most by 150 days of age; lethality begins to be observed at ~55 days
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Allelic
Composition |
Tg(APPV717I)1130Kha/0
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Genetic
Background |
involves: C3H/HeJ * C57BL/6J * FVB/N |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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mortality/aging
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• Background Sensitivity: only 70% of mic die prematurely, compared to 100% of FVB/N-Tg(APPV717I)1130Kha mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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mortality/aging
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• 50% dead at 87 days of age
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behavior/neurological
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• 84% neophobic at 100 days of age
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reproductive system
nervous system
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• hypertrophic astrocytes in the parahippocampal area, hippocampus, amygdala, and cerebral cortex
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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mortality/aging
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• Background Sensitivity: 38% of (CAST x FVB/N)F2 mice and 26% of (CAST x FVB/N)F1 x FVB/N mice die before 150 days of age, whereas no (CAST x FVB/N)F1 mice die prematurely
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Analysis Tools
