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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gapdhm3Neu
mutation 3, Neuherberg
MGI:2183517
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gapdhm3Neu/Gapdhm3Neu C3.Cg-Gapdhm3Neu MGI:3808732
hm2
 		Gapdhm3Neu/Gapdhm3Neu involves: 101/El * C3H/El MGI:3663927
ht3
 		Gapdhm3Neu/Gapdh+ C3.Cg-Gapdhm3Neu MGI:3808733
ht4
 		Gapdhm3Neu/Gapdh+ involves: 101/El * C3H/El MGI:3663928


Genotype
MGI:3808732
hm1
Allelic
Composition		 Gapdhm3Neu/Gapdhm3Neu
Genetic
Background		 C3.Cg-Gapdhm3Neu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gapdhm3Neu mutation (1 available); any Gapdh mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased survivor rate ( J:126359 )
• Background Sensitivity: few (3) homozygous males were recovered in offspring from the first and second generation heterozygous intercrosses, but not in later generations
preweaning lethality, complete penetrance ( J:126359 )
• Background Sensitivity: no homozygotes are recovered from offspring of intercrosses beyond the first and second generations

homeostasis/metabolism
decreased glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity ( J:126359 )
• males exhibit 10% of normal Gapdh activity relative to wild-type




Genotype
MGI:3663927
hm2
Allelic
Composition		 Gapdhm3Neu/Gapdhm3Neu
Genetic
Background		 involves: 101/El * C3H/El
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gapdhm3Neu mutation (1 available); any Gapdh mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, complete penetrance ( J:11216 , J:15477 )
• 1% of homozygotes survive in early generations (all from one line) but are not detected in later generations. (J:15477)
• time point of examination is not given (J:15477)

homeostasis/metabolism
abnormal enzyme/coenzyme activity ( J:15477 )
• 10% erythrocyte enzyme activity in surviving homozygotes




Genotype
MGI:3808733
ht3
Allelic
Composition		 Gapdhm3Neu/Gapdh+
Genetic
Background		 C3.Cg-Gapdhm3Neu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gapdhm3Neu mutation (1 available); any Gapdh mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity ( J:126359 )
• Gapdh activity is approximately 50-55% of wild-type levels




Genotype
MGI:3663928
ht4
Allelic
Composition		 Gapdhm3Neu/Gapdh+
Genetic
Background		 involves: 101/El * C3H/El
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gapdhm3Neu mutation (1 available); any Gapdh mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal enzyme/coenzyme activity ( J:15477 )
• 50% erythrocyte enzyme activity




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Send questions and comments to User Support. 		last database update
05/21/2024
MGI 6.23 		The Jackson Laboratory