Phenotypes associated with this allele

• Allele Symbol: Gapdh^m2Neu
• Allele Name: mutation 2, Neuherberg
• Allele ID: MGI:2183516
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gapdh^m2Neu/Gapdh^m2Neu	C3.Cg-Gapdh^m2Neu	MGI:3808730
hm2	Gapdh^m2Neu/Gapdh^m2Neu	involves: 101/El * C3H/El	MGI:3663925
ht3	Gapdh^m2Neu/Gapdh^+	C3.Cg-Gapdh^m2Neu	MGI:3808731
ht4	Gapdh^m2Neu/Gapdh^+	involves: 101/El * C3H/El	MGI:3663926

Genotype
MGI:3808730

hm1

• Allelic Composition: Gapdh^m2Neu/Gapdh^m2Neu
• Genetic Background: C3.Cg-Gapdh^m2Neu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, incomplete penetrance ( J:126359 )

• number of live implantations is reduced by around 24%, compared to wild-type, suggesting lethality occurs shortly after implantation

Genotype
MGI:3663925

hm2

• Allelic Composition: Gapdh^m2Neu/Gapdh^m2Neu
• Genetic Background: involves: 101/El * C3H/El

mortality/aging

preweaning lethality, complete penetrance ( J:11216 , J:15476 )

• homozygotes are not detected but time point of examination is not given (J:15476)

Genotype
MGI:3808731

ht3

• Allelic Composition: Gapdh^m2Neu/Gapdh⁺
• Genetic Background: C3.Cg-Gapdh^m2Neu

homeostasis/metabolism

decreased glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity ( J:126359 )

• Gapdh activity is approximately 50-55% of wild-type levels

Genotype
MGI:3663926

ht4

• Allelic Composition: Gapdh^m2Neu/Gapdh⁺
• Genetic Background: involves: 101/El * C3H/El

homeostasis/metabolism

abnormal enzyme/coenzyme activity ( J:15476 )

• 50% erythrocyte enzyme activity