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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pth1rtm3Hmk
targeted mutation 3, Henry M Kronenberg
MGI:2183514
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pth1rtm3Hmk/Pth1rtm3Hmk involves: 129S4/SvJae * C57BL/6 MGI:3584051
ht2
 		Pth1rtm1Hmk/Pth1rtm3Hmk involves: 129S4/SvJae * C57BL/6 MGI:3584042
cx3
 		Pth1rtm1Hmk/Pth1rtm3Hmk
Tg(Col2a1-PTHR1*H223R)AHju/? 		involves: 129S4/SvJae * C57BL/6 MGI:3584046


Genotype
MGI:3584051
hm1
Allelic
Composition		 Pth1rtm3Hmk/Pth1rtm3Hmk
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pth1rtm3Hmk mutation (0 available); any Pth1r mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal long bone epiphyseal plate morphology ( J:77683 )
• slightly abnormal growth plates
• exhibit milder phenotypes than compound heterozygous Phthr1tm1Hmk and Phthr1tm3Hmk mutant mice




Genotype
MGI:3584042
ht2
Allelic
Composition		 Pth1rtm1Hmk/Pth1rtm3Hmk
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pth1rtm1Hmk mutation (0 available); any Pth1r mutation (28 available)
Pth1rtm3Hmk mutation (0 available); any Pth1r mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
postnatal growth retardation ( J:77683 )
• begins around 7 days of age

limbs/digits/tail
abnormal limb morphology ( J:77683 )
• start to show limb deformities around 7 days of age
long tibia ( J:77683 )
• slightly greater total length of tibiae

skeleton
long tibia ( J:77683 )
• slightly greater total length of tibiae
abnormal long bone epiphyseal plate morphology ( J:77683 )
• slightly smaller columnar and periarticular regions of growth plates and greater growth plates than in controls
abnormal long bone hypertrophic chondrocyte zone ( J:77683 )
• hypertrophic layer expansion in E17.5 tibial growth plates and prehypertrophic domain expansion due to an increase in early hypertrophic cells
premature chondrocyte differentiation ( J:77683 )
• early chondrocyte differentiation is accelerated as indicated by increased numbers of proliferating hypertrophic chondrocytes and decreased numbers of proliferating columnar chondrocytes




Genotype
MGI:3584046
cx3
Allelic
Composition		 Pth1rtm1Hmk/Pth1rtm3Hmk
Tg(Col2a1-PTHR1*H223R)AHju/?
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pth1rtm1Hmk mutation (0 available); any Pth1r mutation (28 available)
Pth1rtm3Hmk mutation (0 available); any Pth1r mutation (28 available)
Tg(Col2a1-PTHR1*H223R)AHju mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal long bone hypertrophic chondrocyte zone ( J:77683 )
• expansion of fully differentiated hypertrophic chondrocytes in tibia




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory