Phenotypes associated with this allele

• Allele Symbol: Gcm1^tm1Jcc
• Allele Name: targeted mutation 1, James C Cross
• Allele ID: MGI:2183479
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gcm1^tm1Jcc/Gcm1^tm1Jcc	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:3850848
ht2	Gcm1^tm1Jcc/Gcm1^+	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:5441285

Genotype
MGI:3850848

hm1

• Allelic Composition: Gcm1^tm1Jcc/Gcm1^tm1Jcc
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:63123 )

• mice die by E10.5

embryo

decreased embryo size ( J:63123 )

• at E10.5

abnormal chorionic plate morphology ( J:63123 )

• at E9.5, the chorionic plate remains flat and fails to interdigitate with the underlying allantoic mesoderm and blood vessels unlike in wild-type mice

absent placental labyrinth ( J:63123 )

growth/size/body

decreased embryo size ( J:63123 )

• at E10.5

Genotype
MGI:5441285

ht2

• Allelic Composition: Gcm1^tm1Jcc/Gcm1⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

embryo

embryo tissue necrosis ( J:186528 )

• pale cytoplasm, numerous vacuoles and swollen and degenerating mitochondria in SynT-II

abnormal placenta labyrinth morphology ( J:186528 )

• at E17.5, labyrinth exhibit increased area of lustered cuboidal cells compared with wild-type mice

abnormal placental labyrinth vasculature morphology ( J:186528 )

• increased fetoplacental vascularity at E15.5 with increased total number and length of arterial segments with diameters of more than 50 um and increased capillary density

abnormal placenta fetal blood space morphology ( J:186528 )

• increased at E17.5

increased placenta intervillous maternal lacunae size ( J:186528 )

• at E13.5

thick placenta labyrinth ( J:186528 )

• at E13.5 with thick interhemal membrane

abnormal syncytiotrophoblast morphology ( J:186528 )

• thick syncytial layers at E13.5 and E17.5

• abnormal ultrastructure in the 2 syncytial layers at E17.5 with evidence of necrosis (pale cytoplasm, numerous vacuoles and swollen and degenerating mitochondria) in SynT-II

cellular

embryo tissue necrosis ( J:186528 )

• pale cytoplasm, numerous vacuoles and swollen and degenerating mitochondria in SynT-II

increased cell proliferation ( J:186528 )

• 2-fold increase in cell proliferation in the labyrinth at E17.5

cardiovascular system

abnormal placental labyrinth vasculature morphology ( J:186528 )

• increased fetoplacental vascularity at E15.5 with increased total number and length of arterial segments with diameters of more than 50 um and increased capillary density

increased mean systemic arterial blood pressure ( J:186528 )

• wild-type dams carrying heterozygous fetuses exhibit increased mean arterial blood pressure compared with dams carrying wild-type fetuses

• however, dams do not exhibit proteinuria