Phenotypes associated with this allele

• Allele Symbol: Lig1^tm3Dwm
• Allele Name: targeted mutation 3, David W Melton
• Allele ID: MGI:2183413
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lig1^tm3Dwm/Lig1^tm3Dwm	involves: 129P2/OlaHsd * C57BL/6	MGI:3843653

Genotype
MGI:3843653

hm1

• Allelic Composition: Lig1^tm3Dwm/Lig1^tm3Dwm
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:77902 )

N • at 6 and 10 months, mice exhibit normal hematopoiesis

abnormal thymus physiology ( J:77902 )

• from 3 to 14 weeks, the frequency of S-phase cells in the thymus is greater than in wild-type mice

• from 3 to 14 weeks, 27% of mice exhibit a discrete sub-G1 peak unlike wild-type profiles

• however, rates of apoptosis are normal

enlarged spleen ( J:77902 )

• at 3 weeks, spleens are larger than normal

• however, by 5 weeks of age spleen size is normal

reticulocytosis ( J:77902 )

• 2-fold at 19 and 20 days of age

abnormal bone marrow cell physiology ( J:77902 )

• DNA replication occasionally fails in the bone marrow unlike in wild-type bone marrow

• from 3 to 14 weeks, the frequency of S-phase cells in the bone marrow is greater than in wild-type mice

• from 3 to 14 weeks, the frequency of S-phase cells in the bone marrow with abnormal profiles (7% of mice examined) is 2-fold less than in wild-type mice without a discrete G2 peak

• however, rates of apoptosis are normal

cellular

decreased fibroblast proliferation ( J:77902 )

• cultured fibroblasts grow more slowly than wild-type cells

chromosomal instability ( J:77902 )

• the frequency of micronuclei is 2-fold at 7 weeks and 3-fold at 15 months compared to in wild-type mice

neoplasm

increased tumor incidence ( J:77902 )

• mice develop 5 times as many tumors over two years compared to wild-type mice

• mice develop a range of epithelial tumors not observed in wild-type mice

• two superficial tumors with adnexal differentiation develop

increased lymphoma incidence ( J:77902 )

increased adenocarcinoma incidence ( J:77902 )

growth/size/body

decreased body weight ( J:77902 )

• 20% at 6 months

postnatal growth retardation ( J:77902 )

• at 5 weeks

enlarged spleen ( J:77902 )

• at 3 weeks, spleens are larger than normal

• however, by 5 weeks of age spleen size is normal

immune system

abnormal thymus physiology ( J:77902 )

• from 3 to 14 weeks, the frequency of S-phase cells in the thymus is greater than in wild-type mice

• from 3 to 14 weeks, 27% of mice exhibit a discrete sub-G1 peak unlike wild-type profiles

• however, rates of apoptosis are normal

enlarged spleen ( J:77902 )

• at 3 weeks, spleens are larger than normal

• however, by 5 weeks of age spleen size is normal

abnormal spleen physiology ( J:77902 )

• at 3 weeks, the frequency of S-phase cells is 2-fold higher than in wild-type spleens

• at 18 days and 19 days, the frequency of S-phase cells in the spleen is increased compared to in wild-type mice

• at day 19, 4% of mice exhibit an increase in sub-G1 cells in the spleen compared to in wild-type spleens

• the frequency of micronuclei is 2-fold at 7 weeks and 3-fold at 15 months compared to in wild-type mice

endocrine/exocrine glands

abnormal thymus physiology ( J:77902 )

• from 3 to 14 weeks, the frequency of S-phase cells in the thymus is greater than in wild-type mice

• from 3 to 14 weeks, 27% of mice exhibit a discrete sub-G1 peak unlike wild-type profiles

• however, rates of apoptosis are normal