Phenotypes associated with this allele

• Allele Symbol: Itga2^tm1Ztr
• Allele Name: targeted mutation 1, Mary M Zutter
• Allele ID: MGI:2183401
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Itga2^tm1Ztr/Itga2^tm1Ztr	involves: 129S1/Sv * 129X1/SvJ	MGI:3639574
hm2	Itga2^tm1Ztr/Itga2^tm1Ztr	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3628643

Genotype
MGI:3639574

hm1

• Allelic Composition: Itga2^tm1Ztr/Itga2^tm1Ztr
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal platelet physiology ( J:108331 )

• mildly reduced adhesion to collagen under flow is observed in an outside-in platelet activation assay

• severely defective platelet adhesion to collagen under flow is observed in an outside-in activation assay

homeostasis/metabolism

abnormal platelet physiology ( J:108331 )

• mildly reduced adhesion to collagen under flow is observed in an outside-in platelet activation assay

• severely defective platelet adhesion to collagen under flow is observed in an outside-in activation assay

Genotype
MGI:3628643

hm2

• Allelic Composition: Itga2^tm1Ztr/Itga2^tm1Ztr
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

endocrine/exocrine glands

abnormal branching of the mammary ductal tree ( J:77798 )

♀ • the branching complexity is markedly diminished

cellular

decreased cell adhesion ( J:77798 )

• platelets from mutant mice failed to adhere to type I collagen under static conditions nor under shear stress

• platelets from mutant mice aggregated in response to type I collagen with a significantly prolonged lag phase and a decreased rate of aggregation

• mutant mice demonstrated no defect in wound repair

integument

abnormal branching of the mammary ductal tree ( J:77798 )

♀ • the branching complexity is markedly diminished