Analysis Tools
mortality/aging
|
• animals surviving to birth die within 1 day
|
|
• fewer than normal numbers survive until birth; abnormalities apparent at E9.5
|
cardiovascular system
|
• variable penetrance
|
digestive/alimentary system
|
• abnormal digestive system development; terminated at the appendix
|
embryo
|
• incomplete axial turning; variable penetrance
|
sirenomelia
(
J:67375
)
|
• caudal part of body truncated with anterior portion relatively normal
|
|
• irregular folding of neural tube
|
|
• failure of neural tube closure from the forebrain to the hindbrain in 20% of mice
|
|
• irregular somites; variable penetrance
|
limbs/digits/tail
|
• fused at midline; variable penetrance
|
sirenomelia
(
J:67375
)
|
• caudal part of body truncated with anterior portion relatively normal
|
absent tail
(
J:67375
)
renal/urinary system
fused kidneys
(
J:67375
)
|
• kidneys often fused; horseshoe kidneys
|
skeleton
|
• homeotic transformations of vertebrae
|
nervous system
| N |
• normal in 47% of mice
|
|
• minor CNS defects in 33% of mice
|
|
• irregular folding of neural tube
|
|
• failure of neural tube closure from the forebrain to the hindbrain in 20% of mice
|
|
• abnormal hindbrain patterning
|
exencephaly
(
J:67375
)
|
• variable penetrance
|
