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Allele Symbol Allele Name Allele ID |
Nrp2tm1Mkl targeted mutation 1, Michael Klagsbrun MGI:2183238 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice are viable, surviving up to two weeks
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| N |
• normal yolk sac vasculature is observed in homozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the DiI-labeled cells do not respond to Sema3F in cultured telencephalic slices prepared from E10.5 embryos
• migration stream is not biased to either the distal or the proximal side of the Sema3F aggregates, but directed ventrally in cultured telencephalic slices prepared from E10.5 embryos
• increased number of lot cells spread over the deep medial region at E12.5 and E13.5
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• normal surface distribution of lateral olfactory tract cells
• normal total numbers of lateral olfactory tract cells
• about twice as many lateral olfactory tract cells are ectopically distributed over the deep layers at the restricted rostrocaudal middle level at E12.5 and E13.5
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• the DiI-labeled cells do not respond to Sema3F in cultured telencephalic slices prepared from E10.5 embryos
• migration stream is not biased to either the distal or the proximal side of the Sema3F aggregates, but directed ventrally in cultured telencephalic slices prepared from E10.5 embryos
• increased number of lot cells spread over the deep medial region at E12.5 and E13.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• embryos die at E10-10.5, showing longer survival thah double homozygous embryos
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• yolk sacs are of normal size, but lack larger collecting vessels and contain irregular and less dense capillary networks
• vasulature of yolk sac at E10 is characterized by vessel heterogeneity, disorganization, and immaturity
• arterial and venous branching is not seen in yolk sacs at E10
• thickened blood vessels, lack of capillaries, and large avascular spaces between blood vessels are observed, with occasional dead-ended sprouts not connected to other sprouts
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• much smaller than littermates; length of embryo in yolk sac is ~50% of control embryo length
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• much smaller than littermates; length of embryo in yolk sac is ~50% of control embryo length
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• avascular regions, vessel size heterogeneity, and thickened blood vessels are observed
• outflow tract formation is abnormal
• blood vessel density in head region is slightly higher than in Npr1tm1Hfu/Npr1+; Npr2tm1Mkl /Npr2tm1Mkl embryos
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• abnormal formation of dorsal aorta is observed
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• yolk sacs are of normal size, but lack larger collecting vessels and contain irregular and less dense capillary networks
• vasulature of yolk sac at E10 is characterized by vessel heterogeneity, disorganization, and immaturity
• arterial and venous branching is not seen in yolk sacs at E10
• thickened blood vessels, lack of capillaries, and large avascular spaces between blood vessels are observed, with occasional dead-ended sprouts not connected to other sprouts
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• multiple hemorrhages are observed in embryos at E10
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• embryos die at E10-10.5, showing longer survival thah double homozygous embryos
|
|
• yolk sacs are of normal size, but lack larger collecting vessels and contain irregular and less dense capillary networks
• vasulature of yolk sac at E10 is characterized by vessel heterogeneity, disorganization, and immaturity
• thickened blood vessels, lack of capillaries, and large avascular spaces between blood vessels are observed, with occasional dead-ended sprouts not connected to other sprouts
• arterial and venous branching is not seen in yolk sacs at E10
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• embryos show severe vascular impairment at E10
• blood vessels are disorganized, heterogeneous in size, and some show thickening
• blood vessel density is low in the head region, with avascular regions in head and trunk
• small vessel sprouting is seen, but is unconnected to other sprouts and no capillary plexus is formed
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• dorsal aorta is poorly formed, and outflow tract is undetectable
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• yolk sacs are of normal size, but lack larger collecting vessels and contain irregular and less dense capillary networks
• vasulature of yolk sac at E10 is characterized by vessel heterogeneity, disorganization, and immaturity
• thickened blood vessels, lack of capillaries, and large avascular spaces between blood vessels are observed, with occasional dead-ended sprouts not connected to other sprouts
• arterial and venous branching is not seen in yolk sacs at E10
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• multiple hemorrhages are observed in embryos at E10
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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