Phenotypes associated with this allele

• Allele Symbol: Gabra5^tm1.1Uru
• Allele Name: targeted mutation 1.1, Uwe Rudolph
• Allele ID: MGI:2183170
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gabra5^tm1.1Uru/Gabra5^tm1.1Uru	129X1/SvJ-Gabra5^tm1.1Uru	MGI:3844432

Genotype
MGI:3844432

hm1

• Allelic Composition: Gabra5^tm1.1Uru/Gabra5^tm1.1Uru
• Genetic Background: 129X1/SvJ-Gabra5^tm1.1Uru

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal hippocampus CA1 region morphology ( J:77343 )

• loss of extrasynaptic alpha5GABAa receptors in CA1 pyramidal cells

decreased prepulse inhibition ( J:127869 )

• lower prepulse inhibition at all prepulse intensities tested

behavior/neurological

abnormal behavioral response to xenobiotic ( J:77343 )

• mice suffer less impairment to their ability to grasp a wire after treatment with diazepam

enhanced cued conditioning behavior ( J:77343 )

• in 1 second trace fear conditioning tests, mice display greater retention of the conditioned response when retested 48 hours later

decreased fluid intake ( J:128874 )

• lower water consumption

increased locomotor activity ( J:127869 )

• increased distance travelled in an open field test