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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gabra2tm1Uru
targeted mutation 1, Uwe Rudolph
MGI:2183161
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gabra2tm1Uru/Gabra2tm1Uru
Tg(Scn10a-cre)1Rkun/0 		involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA/2 MGI:5140579
cn2
 		Gabra2tm1Uru/Gabra2tm2.1Uru
Tg(Scn10a-cre)1Rkun/0 		involves: C57BL/6 * DBA/2 * SJL MGI:5140581


Genotype
MGI:5140579
cn1
Allelic
Composition		 Gabra2tm1Uru/Gabra2tm1Uru
Tg(Scn10a-cre)1Rkun/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabra2tm1Uru mutation (0 available); any Gabra2 mutation (34 available)
Tg(Scn10a-cre)1Rkun mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
decreased chemically-elicited antinociception ( J:173378 )
• diazepam (DZP)-treated mice exhibit a profound reduction in the antihyperalgesia effect on inflammatory and neuropathic thermal and mechanical hyperalgesia compared with similarly treated wild-type mice

homeostasis/metabolism
decreased physiological sensitivity to xenobiotic ( J:173378 )
• diazepam (DZP)-treated mice exhibit a profound reduction in the antihyperalgesia effect on inflammatory and neuropathic thermal and mechanical hyperalgesia compared with similarly treated wild-type mice




Genotype
MGI:5140581
cn2
Allelic
Composition		 Gabra2tm1Uru/Gabra2tm2.1Uru
Tg(Scn10a-cre)1Rkun/0
Genetic
Background		 involves: C57BL/6 * DBA/2 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabra2tm1Uru mutation (0 available); any Gabra2 mutation (34 available)
Gabra2tm2.1Uru mutation (1 available); any Gabra2 mutation (34 available)
Tg(Scn10a-cre)1Rkun mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
decreased chemically-elicited antinociception ( J:173378 )
• diazepam (DZP)-treated mice exhibit a reduction in the antihyperalgesia effect on inflammatory mechanical hyperalgesia compared with similarly treated wild-type mice that is not as severe as in Gabra2tm1Uru/Gabra2tm1Uru Tg(Scn10a-cre)1Rkun
• however, DZP-induced analgesia of neuropathic mechanical nociception is normal

homeostasis/metabolism
decreased physiological sensitivity to xenobiotic ( J:173378 )
• diazepam (DZP)-treated mice exhibit a reduction in the antihyperalgesia effect on inflammatory mechanical hyperalgesia compared with similarly treated wild-type mice that is not as severe as in Gabra2tm1Uru/Gabra2tm1Uru Tg(Scn10a-cre)1Rkun
• however, DZP-induced analgesia of neuropathic mechanical nociception is normal




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory