Phenotypes associated with this allele

• Allele Symbol: Ppp1r1b^tm1Aaf
• Allele Name: targeted mutation 1, A A Feinberg
• Allele ID: MGI:2183150
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ppp1r1b^tm1Aaf/Ppp1r1b^tm1Aaf	B6.129-Ppp1r1b^tm1Aaf	MGI:3040928
hm2	Ppp1r1b^tm1Aaf/Ppp1r1b^tm1Aaf	B6.129P2-Ppp1r1b^tm1Aaf	MGI:3621166
hm3	Ppp1r1b^tm1Aaf/Ppp1r1b^tm1Aaf	involves: 129P2/OlaHsd * C57BL/6J	MGI:2675259
hm4	Ppp1r1b^tm1Aaf/Ppp1r1b^tm1Aaf	Not Specified	MGI:3040927

Genotype
MGI:3040928

hm1

• Allelic Composition: Ppp1r1b^tm1Aaf/Ppp1r1b^tm1Aaf
• Genetic Background: B6.129-Ppp1r1b^tm1Aaf

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal alcohol consumption ( J:66956 )

• failed to show concentration-dependent response for ethanol, while wild-type controls did

hyperactivity elicited by ethanol administration ( J:66956 )

• greater sensitivity to ethanol-induced locomotor activity than wild-type controls

impaired conditioned place preference behavior ( J:66956 )

• failed to show ethanol-induced conditioned place preference

• ethanol-induced conditioned taste aversion behavior was same as wild-type controls

Genotype
MGI:3621166

hm2

• Allelic Composition: Ppp1r1b^tm1Aaf/Ppp1r1b^tm1Aaf
• Genetic Background: B6.129P2-Ppp1r1b^tm1Aaf

behavior/neurological

impaired behavioral response to addictive substance ( J:107305 )

• treatment of knockouts with psychomimetics D-amphetamine, LSD, and PCP did not cause an increase in repetitive movements or disrupt prepulse inhibition like it did in treated wild-type animals

Genotype
MGI:2675259

hm3

• Allelic Composition: Ppp1r1b^tm1Aaf/Ppp1r1b^tm1Aaf
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

behavior/neurological

impaired behavioral response to addictive substance ( J:78045 )

• reduced catalepsy in response to low dose exposure to raclopride (an antipsychotic), as compared to wild-type controls

impaired behavioral response to cocaine ( J:78045 )

• reduced locomotor response to single, low dose exposure to cocaine, as compared to wild-type controls

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:78045 )

• neurotoxic regimen of methamphetamine failed to damage nerve terminals

• chronic exposure to cocaine failed to induce protein accumulation in striatum seen in wild-type controls

• reduced release of GABA and dopamine from striatum after stimulation with either amphetamine or dopamine

Genotype
MGI:3040927

hm4

• Allelic Composition: Ppp1r1b^tm1Aaf/Ppp1r1b^tm1Aaf
• Genetic Background: Not Specified

behavior/neurological

enhanced behavioral response to cocaine ( J:54156 )

• increased rate of locomotor sensitization to repeated cocaine exposures

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:54156 )

• chronic exposure to cocaine failed to induce protein accumulation in striatum seen in wild-type controls