All Phenotypes Per1<tm1Drw> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Per1^tm1Drw/Per1^tm1Drw	B6.129-Per1^tm1Drw/J	MGI:5634972
hm2	Per1^tm1Drw/Per1^tm1Drw	involves: 129S4/SvJae	MGI:3852063
cx3	Per1^tm1Drw/Per1^tm1Drw Per3^tm1Drw/Per3^tm1Drw	involves: 129S4/SvJae	MGI:3852064
cx4	Per1^tm1Drw/Per1^tm1Drw Per2^tm1Drw/Per2^tm1Drw	involves: 129S4/SvJae	MGI:3852065

Allelic Composition	Per1^tm1Drw/Per1^tm1Drw
Genetic Background	B6.129-Per1^tm1Drw/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Per1^tm1Drw mutation (2 available); any Per1 mutation (62 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal learning/memory/conditioning ( J:219876 )

• mice exhibit impaired learning and memory in the Morris water maze

abnormal impulsive behavior control ( J:219876 )

• mice are impulsive in the open-field

increased vertical activity ( J:219876 )

increased locomotor activity ( J:219876 )

• mice are hyperactive and impulsive in the open-field, traveling a longer distance in 5 min, and showing an increase in the number of line crossings

homeostasis/metabolism

decreased dopamine level ( J:219876 )

• brain dopamine levels are lower in females, but not males

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
attention deficit hyperactivity disorder		DOID:1094	OMIM:143465 OMIM:608903 OMIM:608904 OMIM:608905 OMIM:608906 OMIM:612311 OMIM:612312	J:219876

Allelic Composition	Per1^tm1Drw/Per1^tm1Drw
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Per1^tm1Drw mutation (2 available); any Per1 mutation (62 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

prolonged circadian behavior period ( J:95746 )

• in free-running conditions, the period of temperature rhythm is longer than in wild-type mice

arrhythmic circadian behavior persistence ( J:69626 )

• 9 of 11 mice become arrhythmic after 10 to 14 days when transferred to dark-dark conditions unlike wild-type mice

• for 3 weeks in dark-dark conditions, one mouse exhibited reduced circadian rhythm amplitude compared to in wild-type mice

abnormal sleep pattern ( J:95746 )

• during the 12-hour recovery after 6 hours of prolonged waking, mice exhibit less waking and more short wave sleep compared to similarly treated wild-type mice

abnormal circadian sleep/wake cycle ( J:95746 )

• in free-running dark-dark conditions mice fail to exhibit a change in REM sleep unlike similarly treated wild-type mice

nervous system

abnormal brain wave pattern ( J:95746 )

• recovery after 6 hours of prolonged waking, mice exhibit an increase in delta power lasting 9 hours during the recovery sleep period compared with wild-type mice in which it lasts 3 hours

Allelic Composition	Per1^tm1Drw/Per1^tm1Drw Per3^tm1Drw/Per3^tm1Drw
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Per1^tm1Drw mutation (2 available); any Per1 mutation (62 available)
Per3^tm1Drw mutation (2 available); any Per3 mutation (47 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

arrhythmic circadian behavior persistence ( J:69626 )

• as in Per1^tm1Drw homozygotes

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

arrhythmic circadian behavior persistence ( J:69626 , J:95746 )

• mice immediately lose their rhythmicity when transferred into dark-dark conditions (J:69626)

• in free-running conditions, mice become arrhythmic immediately under dark-dark conditions unlike similarly treated wild-type mice (J:95746)

abnormal sleep pattern ( J:95746 )

• during the 12-hour light segment, mice wake more and have less slow wave sleep compared to wild-type mice

• during the last two-third of the lights-on period, mice exhibit more wakefulness than wild-type mice

• at midday, mice exhibit less REM sleep than wild-type mice

• in dark dark conditions, mice exhibit arrhythmic pattern of time spent in wakefulness, short wave sleep, and REM sleep unlike similarly treated wild-type mice

• however, the amount of sleep obtained in dark-dark conditions is normal

• during entrained conditions, mice exhibit longer wake bouts during the dark period compared with the light period unlike in wild-type mice

• during entrained conditions, mice exhibit longer short wave sleep and REM sleep bouts during the light segment compared with wild-type mice

• arrhythmic mice exhibit even distribution of wake, short wave sleep, and REM bouts during subjective light and dark periods unlike wild-type mice

homeostasis/metabolism

abnormal circadian temperature homeostasis ( J:95746 )

• the acrophase of core temperature is phase-advanced compared to in wild-type mice

nervous system

abnormal brain wave pattern ( J:95746 )

• recovery after 6 hours of prolonged waking, mice exhibit an increase in delta power lasting 12 hours during the recovery sleep period compared with wild-type mice in which it lasts 3 hours

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