Phenotypes associated with this allele

• Allele Symbol: Gab2^tm1Hhg
• Allele Name: targeted mutation 1, Haihua Gu
• Allele ID: MGI:2182762
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gab2^tm1Hhg/Gab2^tm1Hhg	involves: 129S4/SvJae	MGI:3852029

Genotype
MGI:3852029

hm1

• Allelic Composition: Gab2^tm1Hhg/Gab2^tm1Hhg
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:70424 )

N • lymphocyte development is normal

decreased mast cell degranulation ( J:70424 )

• Fcer1a-stimulated bone marrow-derived mast cells exhibit reduced serotonin release compared with similarly treated wild-type cells

• however, TPA plus ionomycin-induced degranulation is normal

decreased mast cell number ( J:70424 )

• mast cell numbers in back and thigh skin are reduced 30% to 50% compared to in wild-type mice whereas peritoneal mast cells are undetectable

• however, ear skin mast cell numbers are normal

decreased susceptibility to type I hypersensitivity reaction ( J:70424 )

• passive cutaneous and systemic anaphylaxis are reduced compared to in similarly treated wild-type mice

hematopoietic system

decreased mast cell degranulation ( J:70424 )

• Fcer1a-stimulated bone marrow-derived mast cells exhibit reduced serotonin release compared with similarly treated wild-type cells

• however, TPA plus ionomycin-induced degranulation is normal

decreased mast cell number ( J:70424 )

• mast cell numbers in back and thigh skin are reduced 30% to 50% compared to in wild-type mice whereas peritoneal mast cells are undetectable

• however, ear skin mast cell numbers are normal

cellular

decreased mast cell degranulation ( J:70424 )

• Fcer1a-stimulated bone marrow-derived mast cells exhibit reduced serotonin release compared with similarly treated wild-type cells

• however, TPA plus ionomycin-induced degranulation is normal