All Phenotypes Nfatc2<tm1Glm> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nfatc2^tm1Glm/Nfatc2^tm1Glm	Not Specified	MGI:3700972
cx2	Nfatc2^tm1Glm/Nfatc2^tm1Glm Nfatc3^tm1Glm/Nfatc3^tm1Glm	involves: 129S2/SvPas	MGI:3525157
cx3	Nfatc2^tm1Glm/Nfatc2^tm1Glm Nfatc3^tm1Glm/Nfatc3^tm1Glm Nfatc4^tm1Grc/Nfatc4^tm1Grc	involves: 129S2/SvPas	MGI:3525159
cx4	Nfatc2^tm1Glm/Nfatc2^tm1Glm Nfatc4^tm1Grc/Nfatc4^tm1Grc	involves: 129S2/SvPas	MGI:3629728

Allelic Composition	Nfatc2^tm1Glm/Nfatc2^tm1Glm
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfatc2^tm1Glm mutation (0 available); any Nfatc2 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

craniofacial phenotype ( J:118753 )

N	• osteoclastogenesis occurs normally; osteoclast numbers are normal

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

postnatal growth retardation ( J:51339 )

• modest

enlarged spleen ( J:51339 )

• massive splenomegaly by 7 weeks of age

• normal architecture is disrupted

• increased numbers of mast cells and eosinophiles

• spontaneous proliferation of splenocytes

hematopoietic system

enlarged spleen ( J:51339 )

• massive splenomegaly by 7 weeks of age

• normal architecture is disrupted

• increased numbers of mast cells and eosinophiles

• spontaneous proliferation of splenocytes

abnormal lymphocyte cell number ( J:51339 )

increased B cell number ( J:51339 )

• increased percentage of B220+ cells in lymph nodes

decreased T cell number ( J:51339 )

• decreased numbers of CD3+ T cells in lymph nodes

• decreased ratio of double positive T cells in lymph nodes

increased T cell number ( J:51339 )

• increased percentage of memory activated T cells in periphery

• increased proportion of double positive T cells in spleen

immune system

enlarged spleen ( J:51339 )

• massive splenomegaly by 7 weeks of age

• normal architecture is disrupted

• increased numbers of mast cells and eosinophiles

• spontaneous proliferation of splenocytes

abnormal lymphocyte cell number ( J:51339 )

increased B cell number ( J:51339 )

• increased percentage of B220+ cells in lymph nodes

decreased T cell number ( J:51339 )

• decreased numbers of CD3+ T cells in lymph nodes

• decreased ratio of double positive T cells in lymph nodes

increased T cell number ( J:51339 )

• increased percentage of memory activated T cells in periphery

• increased proportion of double positive T cells in spleen

abnormal lymph node morphology ( J:51339 )

• lymph node cells increased 2-3 fold

• increased numbers of eosinophiles

increased inflammatory response ( J:51339 )

blepharitis ( J:51339 )

• bilateral blepharitis by for weeks of age

• eyelids with edema and marked inflammatory infiltrates

interstitial pneumonia ( J:51339 )

• inflammatory infiltrate containing lymphocytes, macrophage, neutrophiles, and mast cells

respiratory system

interstitial pneumonia ( J:51339 )

• inflammatory infiltrate containing lymphocytes, macrophage, neutrophiles, and mast cells

vision/eye

blepharitis ( J:51339 )

• bilateral blepharitis by for weeks of age

• eyelids with edema and marked inflammatory infiltrates

Allelic Composition	Nfatc2^tm1Glm/Nfatc2^tm1Glm Nfatc3^tm1Glm/Nfatc3^tm1Glm Nfatc4^tm1Grc/Nfatc4^tm1Grc
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfatc2^tm1Glm mutation (0 available); any Nfatc2 mutation (53 available)
Nfatc3^tm1Glm mutation (1 available); any Nfatc3 mutation (70 available)
Nfatc4^tm1Grc mutation (1 available); any Nfatc4 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

decreased embryo size ( J:83744 )

• smaller than stage matched controls

• stages were not delayed

growth/size/body

decreased embryo size ( J:83744 )

• smaller than stage matched controls

• stages were not delayed

nervous system

abnormal sensory neuron innervation pattern ( J:83744 )

• defects in sensory axon projections found in 100% of triple mutants

• spinal sensory neurons failed to project longitudinally

• commissural axon growth is disrupted

abnormal trigeminal nerve morphology ( J:83744 )

• trigeminal axons stunted at E10.5

abnormal spinal cord dorsal column morphology ( J:83744 )

• dorsal funiculus absent or fragmented

behavior/neurological

decreased anxiety-related response ( J:109139 )

decreased grip strength ( J:109139 )

• mutants display decreased grip strength compared to controls

abnormal locomotor activation ( J:109139 )

• mice show increased locomotor activity compared to BALB/c controls

abnormal social/conspecific interaction behavior ( J:109139 )

• mutants show increased social interaction

muscle

hypotonia ( J:109139 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Down syndrome		DOID:14250	OMIM:190685	J:109139

Allelic Composition	Nfatc2^tm1Glm/Nfatc2^tm1Glm Nfatc4^tm1Grc/Nfatc4^tm1Grc
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfatc2^tm1Glm mutation (0 available); any Nfatc2 mutation (53 available)
Nfatc4^tm1Grc mutation (1 available); any Nfatc4 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

decreased anxiety-related response ( J:109139 )

decreased grip strength ( J:109139 )

• mutants display decreased grip strength compared to controls

abnormal locomotor activation ( J:109139 )

abnormal social/conspecific interaction behavior ( J:109139 )

• mutants show increased social interaction

craniofacial

abnormal cranium morphology ( J:109139 )

• mice have shortened anterior parts of the skull

abnormal neurocranium morphology ( J:109139 )

• mice have a reduced length between the intersection of the parietal and interparietal bones and the nasale

abnormal zygomatic arch morphology ( J:109139 )

• there is a narrowed gap between the anterior aspects of the zygomatic arches

abnormal mandible morphology ( J:109139 )

• double knockouts have shortened distance between numerous landmarks for measuring mandible morphology

muscle

hypotonia ( J:109139 )

skeleton

abnormal cranium morphology ( J:109139 )

• mice have shortened anterior parts of the skull

abnormal neurocranium morphology ( J:109139 )

• mice have a reduced length between the intersection of the parietal and interparietal bones and the nasale

abnormal zygomatic arch morphology ( J:109139 )

• there is a narrowed gap between the anterior aspects of the zygomatic arches

abnormal mandible morphology ( J:109139 )

• double knockouts have shortened distance between numerous landmarks for measuring mandible morphology

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Down syndrome		DOID:14250	OMIM:190685	J:109139

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