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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Per1tm1Saco
targeted mutation 1, Paolo Sassone-Corsi
MGI:2182634
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Per1tm1Saco/Per1tm1Saco B6.129S2-Per1tm1Saco MGI:3845776
hm2
 		Per1tm1Saco/Per1tm1Saco involves: 129S2/SvPas MGI:3845777
hm3
 		Per1tm1Saco/Per1tm1Saco involves: 129S2/SvPas * C57BL/6 MGI:3845775
ht4
 		Per1tm1Saco/Per1+ involves: 129S2/SvPas MGI:3845778


Genotype
MGI:3845776
hm1
Allelic
Composition		 Per1tm1Saco/Per1tm1Saco
Genetic
Background		 B6.129S2-Per1tm1Saco
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Per1tm1Saco mutation (0 available); any Per1 mutation (65 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
shortened circadian behavior period ( J:70850 )
• under constant dark conditions




Genotype
MGI:3845777
hm2
Allelic
Composition		 Per1tm1Saco/Per1tm1Saco
Genetic
Background		 involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Per1tm1Saco mutation (0 available); any Per1 mutation (65 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal circadian behavior phase ( J:98340 )
• following exposure to prolonged light the magnitude of the induced phase delay is significantly larger compared to heterozygous and wild-type controls
abnormal circardian behavior entrainment ( J:98340 )
• impaired entrainment to long day periods under dim light conditions
• mice fail to entrain to long day periods under skeleton light conditions (L/D/L/D, 0.5/16/0.5/7)




Genotype
MGI:3845775
hm3
Allelic
Composition		 Per1tm1Saco/Per1tm1Saco
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Per1tm1Saco mutation (0 available); any Per1 mutation (65 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
shortened circadian behavior period ( J:70850 )
• under constant dark conditions




Genotype
MGI:3845778
ht4
Allelic
Composition		 Per1tm1Saco/Per1+
Genetic
Background		 involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Per1tm1Saco mutation (0 available); any Per1 mutation (65 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal circadian behavior phase ( J:98340 )
• following exposure to prolonged light the magnitude of the induced phase delay is slightly but significantly larger compared to wild-type controls




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory