All Phenotypes Ncam1<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ncam1⁺
wild type
MGI:2182572

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Ncam1^tm1Klc/Ncam1⁺	either: (involves: 129 * C57BL/6J) or (involves: 129 * CD-1)	MGI:3687198
ht2	Ncam1^tm2Mag/Ncam1⁺	involves: 129 * C57BL/6	MGI:2182571
cx3	Mical1^tm1.2Past/Mical1⁺ Ncam1^tm1Cgn/Ncam1⁺	involves: 129 * 129P2/OlaHsd	MGI:7628684

Allelic Composition	Ncam1^tm1Klc/Ncam1⁺
Genetic Background	either: (involves: 129 * C57BL/6J) or (involves: 129 * CD-1)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncam1^tm1Klc mutation (0 available); any Ncam1 mutation (63 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal hippocampus CA3 region morphology ( J:46176 )

• mice have a less pronounced bifurctation of the CA3 region than homozygotes

Allelic Composition	Ncam1^tm2Mag/Ncam1⁺
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncam1^tm2Mag mutation (0 available); any Ncam1 mutation (63 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:34293 )

• fetuses carrying the mutation in the heterozygous state die in utero

• chimeric embryos show abnormalities as early as e8.5, including severe growth retardation and morphological defects

Allelic Composition	Mical1^tm1.2Past/Mical1⁺ Ncam1^tm1Cgn/Ncam1⁺
Genetic Background	involves: 129 * 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mical1^tm1.2Past mutation (0 available); any Mical1 mutation (49 available)
Ncam1^tm1Cgn mutation (1 available); any Ncam1 mutation (63 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal innervation ( J:240378 )

• mice exhibit an increase in the number of mossy fibers in the stratum pyramidale indicating that the characteristic lamination pattern of mossy fibers emanating from the dentate gyrus is altered

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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