Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ggt5tm1Mwl mutation
(0 available);
any
Ggt5 mutation
(26 available)
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mortality/aging
N |
• grossly normal and fertile
• survive at least 1 year
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immune system
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• reduced accumulation of neutrophiles during zymosan A induced peritonitis
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ggt1tm1Zuk mutation
(0 available);
any
Ggt1 mutation
(50 available)
Ggt5tm1Mwl mutation
(0 available);
any
Ggt5 mutation
(26 available)
|
|
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mortality/aging
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• fail to thrive
• 70% die within 4 weeks of life
• lethality rescued if N-acetyl cysteine (NAC) provided in drinking water from birth but not if administration delayed until after weaning
• 84% of NAC treated mice survive to 28 days
• about 50% of NAC treated mice survive to 12 weeks
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growth/size/body
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• rescued by NAC administration in drinking water starting at birth
• weight of NAC treated mice at 8-12 weeks of age 90% of control weight
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reproductive system
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• in NAC treated mice of both sexes when mated to wild-type partners
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vision/eye
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• bilateral
• NAC treatment partially prevents cataract formation
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pigmentation
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• gray coat color
• more normal coat color in NAC treated mice
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integument
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• gray coat color
• more normal coat color in NAC treated mice
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