Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pth1rtm1Hmk mutation
(0 available);
any
Pth1r mutation
(28 available)
Pth1rtm2Hmk mutation
(0 available);
any
Pth1r mutation
(28 available)
Pthlhtm1Hmk mutation
(0 available);
any
Pthlh mutation
(19 available)
Tg(Bglap2-cre)1Kry mutation
(0 available)
Tg(Col2a1-PTHLH)1Ecw mutation
(0 available)
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skeleton
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• increase in tibia length
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• exhibit ectopically differentiated chondrocytes
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• eutopic hypertrophic chondrocyte differentiation is stimulated
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limbs/digits/tail
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• increase in tibia length
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pth1rtm1Hmk mutation
(0 available);
any
Pth1r mutation
(28 available)
Pth1rtm2Hmk mutation
(0 available);
any
Pth1r mutation
(28 available)
Pthlhtm1Hmk mutation
(0 available);
any
Pthlh mutation
(19 available)
Tg(Col2a1-PTHLH)1Ecw mutation
(0 available)
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skeleton
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• rescued growth plate lacks hypertrophic chondrocytes and columnar cells
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• bone formation is suppressed
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limbs/digits/tail
immune system
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• bone marrow formation is suppressed
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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Subgross analysis of skeletons of Tg(Col2a1-PTHLH)1Ecw/0 mice
growth/size/body
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• small in size although growth rate is similar to controls
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limbs/digits/tail
skeleton
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• shortening and bowing of the long bones
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• vertebral length is reduced at 3 weeks of age
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• growth plates of long bones are thickened
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• delay in chondrocyte differentiation
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• delay in endochondrial bone ossification and profoundly altered sequence of endochondral bone development
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• sequence of endochondral bone development is altered such that chondrocyte hypertrophy begins at the periphery of long bones rather than in the middle and initially leads to formation of pseudogrowth plates
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• born with a cartilaginous endochondral skeleton
• ossification centers are not evident or are small and persist as cartilaginous primorida in many skeletal elements that form by endochondral ossification, however by 7 weeks of age, the delays in chondrocyte differentiation and ossification are largely corrected, leaving foreshortened and misshapen but histologically near-normal bones
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Analysis Tools