All Phenotypes Dazl<tm1Hjc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Dazl^tm1Hjc
targeted mutation 1, Howard J Cooke
MGI:2181904

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dazl^tm1Hjc/Dazl^tm1Hjc	involves: 129P2/OlaHsd * MF1	MGI:2659051
ht2	Dazl^tm1Hjc/Dazl⁺	involves: 129P2/OlaHsd * MF1	MGI:2659052
cx3	Dazl^tm1Hjc/Dazl⁺ Pum2^Gt(XE772)Byg/Pum2^Gt(XE772)Byg	involves: 129P2/OlaHsd * C57BL/6	MGI:3813702

Allelic Composition	Dazl^tm1Hjc/Dazl^tm1Hjc
Genetic Background	involves: 129P2/OlaHsd * MF1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dazl^tm1Hjc mutation (3 available); any Dazl mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

absent ovarian follicles ( J:42612 )

• neither follicles nor ova were observed

small ovary ( J:42612 )

abnormal seminiferous tubule morphology ( J:42612 , J:71070 )

• fewer tubules per cross-section (J:42612)

• reduced tubule diameter relative to wild-type (J:71070)

small testis ( J:42612 )

• 3-fold reduction in testis mass relative to wild-type littermates

reproductive system

absent ovarian follicles ( J:42612 )

• neither follicles nor ova were observed

small ovary ( J:42612 )

abnormal seminiferous tubule morphology ( J:42612 , J:71070 )

• fewer tubules per cross-section (J:42612)

• reduced tubule diameter relative to wild-type (J:71070)

small testis ( J:42612 )

• 3-fold reduction in testis mass relative to wild-type littermates

arrest of spermatogenesis ( J:42612 , J:71070 )

(J:42612)

• spermatogonia were contained within 76% of adult tubules (J:71070)

• spermatocytes were contained within 3% of adult tubules (J:71070)

• failure of A aligned spermatogonia to differentiate into A1 spermatogonia (J:71070)

female infertility ( J:42612 )

male infertility ( J:42612 )

Allelic Composition	Dazl^tm1Hjc/Dazl⁺
Genetic Background	involves: 129P2/OlaHsd * MF1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dazl^tm1Hjc mutation (3 available); any Dazl mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal male germ cell morphology ( J:42612 )

• 60% of sperm are visibly abnormal

oligozoospermia ( J:42612 )

• reduced amount of epididymal sperm

cellular

abnormal male germ cell morphology ( J:42612 )

• 60% of sperm are visibly abnormal

oligozoospermia ( J:42612 )

• reduced amount of epididymal sperm

Allelic Composition	Dazl^tm1Hjc/Dazl⁺ Pum2^Gt(XE772)Byg/Pum2^Gt(XE772)Byg
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dazl^tm1Hjc mutation (3 available); any Dazl mutation (30 available)
Pum2^Gt(XE772)Byg mutation (1 available); any Pum2 mutation (99 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:123531 )

N	• males are fertile with sperm counts that do not differ significantly from controls unlike mice homozygous for Dazl^tm1Hjc

decreased testis weight ( J:123531 )

endocrine/exocrine glands

decreased testis weight ( J:123531 )

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