Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
PhexHyp-2J mutation
(1 available);
any
Phex mutation
(21 available)
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growth/size/body
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• all females have a squared trunk
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limbs/digits/tail
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• shortened hind limbs are seen
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
PhexHyp-2J mutation
(1 available);
any
Phex mutation
(21 available)
|
|
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craniofacial
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• at 12 weeks the skull is significantly shorter in length and width with lower areal bone mineral density compared to controls
• the distance between the inner tips of the orbital sockets (inner canthal distance) is increased
• skull height, nose length, and lower/upper jaw length are unaffected
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growth/size/body
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• all males have significantly lower body weights (~25% less than controls) and a squared trunk
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hearing/vestibular/ear
N |
• mean auditory brainstem response thresholds are not different from controls
• no degeneration of the organ of Corti or spiral ganglion is seen
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• a precipitate is found in the scala tympani of the cochlea
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homeostasis/metabolism
limbs/digits/tail
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• the fibula is shortened and splayed
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• the tibia is shortened and splayed
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• growth plates of the knee are thickened and irregular
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• shortened hind limbs are seen
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skeleton
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• at 12 weeks the skull is significantly shorter in length and width with lower areal bone mineral density compared to controls
• the distance between the inner tips of the orbital sockets (inner canthal distance) is increased
• skull height, nose length, and lower/upper jaw length are unaffected
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• growth plates of the knee are thickened and irregular
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• disorganized femoral growth plates
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• the long bones are shortened
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• the fibula is shortened and splayed
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• the tibia is shortened and splayed
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• the long bones are thickened
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• between 6 and 40 weeks of age under-mineralized bone is present throughout the body
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