Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2rtm2Arge mutation
(0 available);
any
Igf2r mutation
(98 available)
|
|
|
mortality/aging
|
• most mice die around the time of birth but some survive
• Background Sensitivity: survival rate is dependent on strain background
|
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• most mice die around the time of birth but some survive
|
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• some mice die postnatally
|
reproductive system
|
• 10 of 16 surviving females exhibit distention of the uterus due to an imperforate vagina
|
|
• 10 of 16 surviving females exhibit a 6-fold increase in uterus size compared to in wild-type mice
|
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• 10 of 16 surviving females exhibit distention of the uterus due to an imperforate vagina
|
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• 2 of 3 females are infertile
|
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• 1 of 6 males is infertile
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cardiovascular system
|
• the ventricular septum width is increased compared to in wild-type mice
|
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• heart weight is 4-fold more than in wild-type mice
|
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• mice exhibit a 38% increase in mural thickening of the left ventricle compared to in wild-type mice without hyperplasia
• mice exhibit a 4-fold larger wall volume compared to in wild-type mice
|
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• an 89% increase compared to in wild-type mice
|
|
• perinatal lethality is likely caused by decompensated heart failure
|
homeostasis/metabolism
growth/size/body
|
• heart weight is 4-fold more than in wild-type mice
|
|
• mice are 35% to 40% larger than wild-type mice at birth
|
|
• water content at E17.5 and E18.5 is increased compared to in wild-type mice
|
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• mice are 35% to 40% larger than wild-type mice at E18.5
|
limbs/digits/tail
embryo
liver/biliary system
nervous system
renal/urinary system
hematopoietic system
|
• immature (nucleated) red blood cells persist in the embryonic circulation unlike in wild-type mice
|
respiratory system
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2rtm2Arge mutation
(0 available);
any
Igf2r mutation
(98 available)
|
|
|
growth/size/body
|
• birth weight is 140% of normal
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2rtm2Arge mutation
(0 available);
any
Igf2r mutation
(98 available)
|
|
|
mortality/aging
|
• no mice survive the postnatal period
|
Allelic Composition |
Igf2rtm2Arge/Igf2r+
|
|
Genetic Background |
involves: 129 |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2rtm2Arge mutation
(0 available);
any
Igf2r mutation
(98 available)
|
|
|
mortality/aging
|
• when this allele is inherited maternally, most mice die around the time of birth but some survive
• Background Sensitivity: survival rate is dependent on strain background
|
|
• when this allele is inherited maternally, most mice die around the time of birth but some survive
• however, when this allele is inherited paternally no abnormal lethality is observed
|
|
• when this allele is inherited maternally, some mice die postnatally
|
reproductive system
|
• when this allele is inherited maternally, 10 of 16 surviving females exhibit distention of the uterus due to an imperforate vagina
|
|
• when this allele is inherited maternally, 10 of 16 surviving females exhibit a 6-fold increase in uterus size compared to in wild-type mice
|
|
• when this allele is inherited maternally, 10 of 16 surviving females exhibit distention of the uterus due to an imperforate vagina
|
|
• when this allele is inherited maternally, 2 of 3 females are infertile
|
|
• when this allele is inherited maternally, 1 of 6 males is infertile
|
cardiovascular system
|
• when this allele is inherited maternally, the ventricular septum width is increased compared to in wild-type mice
|
|
• when this allele is inherited maternally
|
|
• when this allele is inherited maternally, heart weight is 4-fold more than in wild-type mice
|
|
• when this allele is inherited maternally
|
|
• when this allele is inherited maternally, mice exhibit a 38% increase in mural thickening of the left ventricle compared to in wild-type mice without hyperplasia
• when this allele is inherited maternally, mice exhibit a 4-fold larger wall volume compared to in wild-type mice
|
|
• an 89% increase compared to in wild-type mice when this allele is inherited maternally
|
|
• when this allele is inherited maternally
|
|
• when this allele is inherited maternally, perinatal lethality is likely caused by decompensated heart failure
|
homeostasis/metabolism
growth/size/body
|
• when this allele is inherited maternally
|
|
• when this allele is inherited maternally, heart weight is 4-fold more than in wild-type mice
|
|
• when this allele is inherited maternally
|
|
• beginning at E13.5 when this allele is inherited maternally
|
|
• when this allele is inherited maternally, mice are 35% to 40% larger than wild-type mice at birth
|
|
• when this allele is inherited maternally, water content at E17.5 and E18.5 is increased compared to in wild-type mice
|
|
• when this allele is inherited maternally, mice are 35% to 40% larger than wild-type mice at E18.5
|
|
• when this allele is inherited maternally
|
|
• when this allele is inherited maternally
|
|
• when this allele is inherited maternally
|
|
• when this allele is inherited maternally
|
|
• when this allele is inherited maternally
|
limbs/digits/tail
|
• postaxial when this allele is inherited maternally
|
|
• when this allele is inherited maternally
|
embryo
|
• beginning at E13.5 when this allele is inherited maternally
|
|
• beginning at E13.5 when this allele is inherited maternally
|
liver/biliary system
|
• when this allele is inherited maternally
|
|
• when this allele is inherited maternally
|
nervous system
|
• when this allele is inherited maternally
|
renal/urinary system
|
• when this allele is inherited maternally
|
hematopoietic system
|
• when this allele is inherited maternally, immature (nucleated) red blood cells persist in the embryonic circulation unlike in wild-type mice
|
respiratory system
|
• when this allele is inherited maternally
|
|
• when this allele is inherited maternally
|
Allelic Composition |
Igf2rtm2Arge/Igf2r+
|
|
Genetic Background |
involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2rtm2Arge mutation
(0 available);
any
Igf2r mutation
(98 available)
|
|
|
growth/size/body
|
• when Igf2rtm2Arge is inherited maternally, birth weight is 140% of normal
|
Allelic Composition |
Igf2rtm2Arge/Igf2r+
|
|
Genetic Background |
involves: 129/Sv * C57BL/6J * MF1 |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2rtm2Arge mutation
(0 available);
any
Igf2r mutation
(98 available)
|
|
|
mortality/aging
|
• Background Sensitivity: when this allele is inherited maternally, 0.7% of mice survive the postnatal period compared to 16.2% on an 129/Sv MF1 background
|
|
• when this allele is inherited maternally, some mice die between E17.5 and E18.5
|
|
• Background Sensitivity: when this allele is inherited maternally, 0.7% of mice survive the postnatal period compared to 16.2% on an 129/Sv MF1 background
|
Allelic Composition |
Igf2rtm2Arge/Igf2r+
|
|
Genetic Background |
involves: 129/Sv * MF1 |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2rtm2Arge mutation
(0 available);
any
Igf2r mutation
(98 available)
|
|
|
mortality/aging
|
• Background Sensitivity: when this allele is inherited maternally, 16.2% of mice survive beyond the postnatal period compared to 0.7% on a 129/Sv C57BL/6 MF1 background
|
|
• Background Sensitivity: when this allele is inherited maternally, 16.2% of mice survive beyond the postnatal period compared to 0.7% on a 129/Sv C57BL/6 MF1 background
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2rtm2Arge mutation
(0 available);
any
Igf2r mutation
(98 available)
Igf2tm1Rob mutation
(1 available);
any
Igf2 mutation
(25 available)
M6prtm1Hlk mutation
(0 available);
any
M6pr mutation
(25 available)
|
|
|
mortality/aging
N |
• when Igf2tm1Rob is inherited paternally and Igf2rtm2Arge is inherited maternally, mice are viable
|
growth/size/body
|
• when Igf2tm1Rob is inherited paternally and Igf2rtm2Arge is inherited maternally, mice are dwarfed
|
reproductive system
N |
• when Igf2tm1Rob is inherited paternally and Igf2rtm2Arge is inherited maternally, mice are fertile
|
Allelic Composition |
Igf2tm1Rob/Igf2+ Igf2rtm2Arge/Igf2r+
|
|
Genetic Background |
involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2rtm2Arge mutation
(0 available);
any
Igf2r mutation
(98 available)
Igf2tm1Rob mutation
(1 available);
any
Igf2 mutation
(25 available)
|
|
|
embryo
|
• when Igf2tm1Rob is inherited paternally and Igf2rtm2Arge is inherited maternally, placenta size is 67% of normal at E18.5
|
growth/size/body
|
• when Igf2tm1Rob is inherited paternally and Igf2rtm2Arge is inherited maternally, birth weight is 73.8% of normal
• when Igf2tm1Rob and Igf2rtm2Arge are inherited paternally, birth weight is 61.5% of normal
|
|
• when Igf2tm1Rob and Igf2rtm2Arge are inherited maternally, birth weight is 140% of normal
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1rtm1Arge mutation
(0 available);
any
Igf1r mutation
(86 available)
Igf2rtm2Arge mutation
(0 available);
any
Igf2r mutation
(98 available)
|
|
|
growth/size/body
|
• birth weight is 109% of normal
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1rtm1Arge mutation
(0 available);
any
Igf1r mutation
(86 available)
Igf2rtm2Arge mutation
(0 available);
any
Igf2r mutation
(98 available)
|
|
|
growth/size/body
|
• when Igf2rtm2Arge is inherited paternally, birth weight is 45.9% of wild-type
|
|
• when Igf2rtm2Arge is inherited maternally, birth weight is 109% of normal
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2rtm2Arge mutation
(0 available);
any
Igf2r mutation
(98 available)
Igf2tm1Rob mutation
(1 available);
any
Igf2 mutation
(25 available)
M6prtm1Hlk mutation
(0 available);
any
M6pr mutation
(25 available)
|
|
|
mortality/aging
|
• when Igf2rtm2Arge is inherited maternally, mice die within 4 weeks of birth
|
behavior/neurological
|
• when Igf2rtm2Arge is inherited maternally, mice exhibit a waddling gait
|
growth/size/body
|
• when Igf2rtm2Arge is inherited maternally, mice are dwarfed
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2rtm2Arge mutation
(0 available);
any
Igf2r mutation
(98 available)
Igf2tm1Rob mutation
(1 available);
any
Igf2 mutation
(25 available)
M6prtm1Hlk mutation
(0 available);
any
M6pr mutation
(25 available)
|
|
|
mortality/aging
|
• when Igf2tm1Rob is inherited paternally and Igf2rtm2Arge is inherited maternally, mice die within 4 weeks of birth
|
growth/size/body
|
• when Igf2tm1Rob is inherited paternally and Igf2rtm2Arge is inherited maternally, mice are dwarfed
|
behavior/neurological
|
• when Igf2tm1Rob is inherited paternally and Igf2rtm2Arge is inherited maternally, mice exhibit a waddling gait
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2rtm2Arge mutation
(0 available);
any
Igf2r mutation
(98 available)
Igf2tm1Rob mutation
(1 available);
any
Igf2 mutation
(25 available)
M6prtm1Hlk mutation
(0 available);
any
M6pr mutation
(25 available)
|
|
|
mortality/aging
N |
• when Igf2rtm2Arge is inherited maternally, mice are viable
|
growth/size/body
|
• when Igf2rtm2Arge is inherited maternally, mice are dwarfed
|
reproductive system
N |
• when Igf2rtm2Arge is inherited maternally, mice are fertile
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1rtm1Arge mutation
(0 available);
any
Igf1r mutation
(86 available)
Igf2rtm2Arge mutation
(0 available);
any
Igf2r mutation
(98 available)
Igf2tm1Rob mutation
(1 available);
any
Igf2 mutation
(25 available)
|
|
|
embryo
|
• when Igf2tm1Rob is inherited paternally and Igf2rtm2Arge is inherited maternally, placenta size is 67% of normal at E18.5
• when Igf2tm1Rob and Igf2rtm2Arge are inherited paternally, placenta size is 67% of normal at E18.5
|
growth/size/body
|
• when Igf2tm1Rob is inherited paternally and Igf2rtm2Arge is inherited maternally, birth weight is 34.4% of normal
• when Igf2tm1Rob and Igf2rtm2Arge are inherited paternally, birth weight is 33.6% of normal
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1rtm1Arge mutation
(0 available);
any
Igf1r mutation
(86 available)
Igf2rtm2Arge mutation
(0 available);
any
Igf2r mutation
(98 available)
Igf2tm1Rob mutation
(1 available);
any
Igf2 mutation
(25 available)
|
|
|
embryo
|
• when Igf2tm1Rob is inherited paternally, placenta size is 67% of normal at E18.5
|
growth/size/body
|
• when Igf2tm1Rob is inherited paternally, birth weight is 34.4% of normal
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1rtm1Arge mutation
(0 available);
any
Igf1r mutation
(86 available)
Igf2rtm2Arge mutation
(0 available);
any
Igf2r mutation
(98 available)
Igf2tm1Rob mutation
(1 available);
any
Igf2 mutation
(25 available)
|
|
|
embryo
|
• placenta size is 67% of normal at E18.5
|
growth/size/body
|
• birth weight is 34.4% of normal
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2rtm2Arge mutation
(0 available);
any
Igf2r mutation
(98 available)
Igf2tm1Rob mutation
(1 available);
any
Igf2 mutation
(25 available)
|
|
|
embryo
|
• placenta size is 67% of normal at E18.5
|
growth/size/body
|
• birth weight is 73.8% of normal
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2rtm2Arge mutation
(0 available);
any
Igf2r mutation
(98 available)
Igf2tm1Rob mutation
(1 available);
any
Igf2 mutation
(25 available)
|
|
|
embryo
|
• when Igf2rtm2Arge is inherited maternally, placenta size is 67% of normal at E18.5
|
growth/size/body
|
• when Igf2rtm2Arge is inherited maternally, birth weight is 73.8% of normal
• when Igf2rtm2Arge is inherited paternally, birth weight is 61.5% of normal
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2rtm2Arge mutation
(0 available);
any
Igf2r mutation
(98 available)
Igf2tm1Rob mutation
(1 available);
any
Igf2 mutation
(25 available)
|
|
|
embryo
|
• when Igf2tm1Rob is inherited paternally, placenta size is 67% of normal at E18.5
|
growth/size/body
|
• when Igf2tm1Rob is inherited paternally, birth weight is 73.8% of normal
|
|
• when Igf2tm1Rob is inherited maternally, birth weight is 140% of normal
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1rtm1Arge mutation
(0 available);
any
Igf1r mutation
(86 available)
Igf2rtm2Arge mutation
(0 available);
any
Igf2r mutation
(98 available)
|
|
|
mortality/aging
|
• most mice die perinatally with some exceptions
|
|
• most mice die perinatally with some exceptions
|
growth/size/body
|
• birth weight is 135% of normal
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1rtm1Arge mutation
(0 available);
any
Igf1r mutation
(86 available)
Igf2rtm2Arge mutation
(0 available);
any
Igf2r mutation
(98 available)
|
|
|
mortality/aging
|
• when Igf2rtm2Arge is inherited maternally, most mice die perinatally with some exceptions
|
|
• when Igf2rtm2Arge is inherited maternally, most mice die perinatally with some exceptions
|
growth/size/body
|
• when Igf2rtm2Arge is inherited maternally, birth weight is 135% of normal
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1rtm1Arge mutation
(0 available);
any
Igf1r mutation
(86 available)
Igf2rtm2Arge mutation
(0 available);
any
Igf2r mutation
(98 available)
|
|
|
mortality/aging
reproductive system
|
• mice exhibit decreased litter size due to decreased maternal care
• however, litter survival can be increased by fostering pups
|
embryo
behavior/neurological
|
• females do not care for their neonates whose survival can be increased by fostering
|
growth/size/body
|
• mice exhibit reduced growth after P1 but catch up by P70
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1rtm1Arge mutation
(0 available);
any
Igf1r mutation
(86 available)
Igf2rtm2Arge mutation
(0 available);
any
Igf2r mutation
(98 available)
|
|
|
mortality/aging
N |
• when Igf2rtm2Arge is inherited maternally, survival is normal
|
reproductive system
|
• when Igf2rtm2Arge is inherited maternally, mice exhibit decreased litter size due to decreased maternal care
• however, litter survival can be increased by fostering pups
|
embryo
|
• when this allele is inherited maternally
|
behavior/neurological
|
• when Igf2rtm2Arge is inherited maternally, females do not care for their neonates whose survival can be increased by fostering
|
growth/size/body
N |
• when Igf2rtm2Arge is inherited maternally, birth weight is normal
|
|
• when Igf2rtm2Arge is inherited paternally, birth weight is 47% of normal
|
|
• when Igf2rtm2Arge is inherited maternally, mice exhibit reduced growth after P1 but catch up by P70
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1rtm1Arge mutation
(0 available);
any
Igf1r mutation
(86 available)
Igf2rtm2Arge mutation
(0 available);
any
Igf2r mutation
(98 available)
|
|
|
mortality/aging
|
• 3.7% of mice survive postnatally
|
|
• 3.7% of mice survive postnatally
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1rtm1Arge mutation
(0 available);
any
Igf1r mutation
(86 available)
Igf2rtm2Arge mutation
(0 available);
any
Igf2r mutation
(98 available)
|
|
|
mortality/aging
|
• when this allele is inherited maternally, 7.3% of mice survive postnatally
|
|
• when this allele is inherited maternally, 7.3% of mice survive postnatally
|