Phenotypes associated with this allele

• Allele Symbol: Stat5b^tm1Hwd
• Allele Name: targeted mutation 1, Helen W Davey
• Allele ID: MGI:2181592
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Stat5b^tm1Hwd/Stat5b^tm1Hwd	involves: 129 * BALB/c	MGI:3688439
hm2	Stat5b^tm1Hwd/Stat5b^tm1Hwd	involves: C57BL/6	MGI:3688423
cx3	Akr1c18^tm1Jni/Akr1c18^tm1Jni Stat5b^tm1Hwd/Stat5b^tm1Hwd	involves: 129P2/OlaHsd * C57BL/6	MGI:3527341

Genotype
MGI:3688439

hm1

• Allelic Composition: Stat5b^tm1Hwd/Stat5b^tm1Hwd
• Genetic Background: involves: 129 * BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

decreased total body fat amount ( J:41784 )

• both males and females exhibit less adipose tissue

• weight of sublumbar adipose tissue in females is reduced to 36% of wild-type and to 69% of wild-type in males

endocrine/exocrine glands

abnormal mammary gland development ( J:41784 )

♀ • mammary gland development is impaired although milk proteins are expressed

hypolactation ( J:41784 )

♀ • produce insufficient milk to feed pups

growth/size/body

decreased body weight ( J:41784 )

• males, but not females, show decreased body weight so that by 4-5 weeks of age, males are 27% lighter than wild-type and this difference persists beyond puberty

obese ( J:41784 )

• obesity becomes apparent in some mutants beginning at about 9 weeks of age, showing large testicular fat pads and greater amounts of abdominal fat

enlarged liver ( J:41784 )

• seen in some homozygotes

homeostasis/metabolism

decreased circulating insulin-like growth factor I level ( J:41784 )

• plasma IGF-1 concentrations are lower in both males and females

increased circulating growth hormone level ( J:41784 )

• males, but not females, exhibit normal to elevated plasma growth hormone levels

decreased urine major urinary protein level ( J:41784 )

• MUP, a family of alpha2-microglobulin-related liver secretory proteins that comprise a major protein component of mouse urine, levels in male urine are similar to the amounts seen in female urine which is less than seen in wild-type males

liver/biliary system

enlarged liver ( J:41784 )

• seen in some homozygotes

pale liver ( J:41784 )

• seen in some homozygotes

abnormal liver physiology ( J:41784 )

• male-specific liver gene expression is decreased to wild-type female levels in homozygous males, while female-predominant liver gene products are increased in males to a level intermediate between wild-type male and female levels

renal/urinary system

decreased urine major urinary protein level ( J:41784 )

• MUP, a family of alpha2-microglobulin-related liver secretory proteins that comprise a major protein component of mouse urine, levels in male urine are similar to the amounts seen in female urine which is less than seen in wild-type males

reproductive system

increased miscarriage rate ( J:41784 )

♀ • females consistently abort between day 8 and 17 of pregnancy, with no obvious maternal, placental or fetal defects; deaths are not associated with genotype of pups

♀ • subcutaneous administration of progesterone maintains pregnancy

integument

abnormal mammary gland development ( J:41784 )

♀ • mammary gland development is impaired although milk proteins are expressed

hypolactation ( J:41784 )

♀ • produce insufficient milk to feed pups

abnormal hair growth ( J:41784 )

• exhibit a delay of at least 2 weeks in the commencement of second-generation hair growth

sparse hair ( J:41784 )

• seen in some homozygotes

Genotype
MGI:3688423

hm2

• Allelic Composition: Stat5b^tm1Hwd/Stat5b^tm1Hwd
• Genetic Background: involves: C57BL/6

immune system

decreased T cell proliferation ( J:112035 )

• splenocytes exhibit greatly diminished proliferation in response to IL-2 and IL-15 and a combination of PMA and IL-4

abnormal lymphocyte morphology ( J:112035 )

abnormal double-negative T cell morphology ( J:112035 )

• among the double negative cells, there is a moderate decrease in the percentage of CD44+CD25- cells and an increase in the percentage of CD44-CD25+ cells

abnormal lymphocyte cell number ( J:112035 )

• the T/B cell ratio is slightly decreased

decreased thymocyte number ( J:112035 )

• thymocyte numbers are modestly diminished

decreased NK cell number ( J:112035 )

• exhibit a decrease in IL2-Rbeta+ NK cells

• percentage of NK (CD3-DX5+) cells is diminished (about 55% of the percentage seen in wild-type)

decreased CD8-positive, alpha-beta T cell number ( J:112035 )

• exhibit diminished numbers of single positive splenocytes; the number of CD4-CD8+ splenocytes is reduced, whereas, the number of CD4+CD8- cells is only slightly affected

decreased splenocyte number ( J:112035 )

• exhibit decreased numbers of splenocytes in the periphery

impaired natural killer cell mediated cytotoxicity ( J:112035 )

• NK cytolytic activity is impaired

hematopoietic system

decreased T cell proliferation ( J:112035 )

• splenocytes exhibit greatly diminished proliferation in response to IL-2 and IL-15 and a combination of PMA and IL-4

abnormal lymphocyte morphology ( J:112035 )

abnormal double-negative T cell morphology ( J:112035 )

• among the double negative cells, there is a moderate decrease in the percentage of CD44+CD25- cells and an increase in the percentage of CD44-CD25+ cells

abnormal lymphocyte cell number ( J:112035 )

• the T/B cell ratio is slightly decreased

decreased thymocyte number ( J:112035 )

• thymocyte numbers are modestly diminished

decreased NK cell number ( J:112035 )

• percentage of NK (CD3-DX5+) cells is diminished (about 55% of the percentage seen in wild-type)

• exhibit a decrease in IL2-Rbeta+ NK cells

decreased CD8-positive, alpha-beta T cell number ( J:112035 )

• exhibit diminished numbers of single positive splenocytes; the number of CD4-CD8+ splenocytes is reduced, whereas, the number of CD4+CD8- cells is only slightly affected

decreased splenocyte number ( J:112035 )

• exhibit decreased numbers of splenocytes in the periphery

impaired natural killer cell mediated cytotoxicity ( J:112035 )

• NK cytolytic activity is impaired

endocrine/exocrine glands

decreased thymocyte number ( J:112035 )

• thymocyte numbers are modestly diminished

cellular

decreased T cell proliferation ( J:112035 )

• splenocytes exhibit greatly diminished proliferation in response to IL-2 and IL-15 and a combination of PMA and IL-4

Genotype
MGI:3527341

cx3

• Allelic Composition: Akr1c18^tm1Jni/Akr1c18^tm1Jni; Stat5b^tm1Hwd/Stat5b^tm1Hwd
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

reproductive system

reproductive system phenotype ( J:95560 )

N • corrected mid gestation abortion of embryos seen in Stat5b^tm1Hwd homozygotes