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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Phlda2tm2Bty
targeted mutation 2, Benjamin Tycko
MGI:2181543
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Phlda2tm2Bty/Phlda2tm2Bty involves: 129/Sv * C57BL/6 MGI:3042597
cx2
 		Igf2tm1Kel/Igf2+
Phlda2tm2Bty/Phlda2+ 		involves: 129/Sv * C57BL/6 MGI:3042599
cx3
 		Phlda2tm2Bty/Phlda2tm2Bty
Phlda3tm1Bty/Phlda3tm1Bty 		involves: 129/Sv * C57BL/6 MGI:3845042


Genotype
MGI:3042597
hm1
Allelic
Composition		 Phlda2tm2Bty/Phlda2tm2Bty
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Phlda2tm2Bty mutation (0 available); any Phlda2 mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
increased spongiotrophoblast size ( J:76871 )
• spongiotrophoblast is expanded
increased trophoblast glycogen cell number ( J:76871 )
• there is an increased number of glycogen containing cells

growth/size/body
decreased fetal weight ( J:76871 )
• fetal weight was decreased 13% compared to controls

cellular




Genotype
MGI:3042599
cx2
Allelic
Composition		 Igf2tm1Kel/Igf2+
Phlda2tm2Bty/Phlda2+
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2tm1Kel mutation (0 available); any Igf2 mutation (29 available)
Phlda2tm2Bty mutation (0 available); any Phlda2 mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
increased spongiotrophoblast size ( J:76871 )
• spongiotrophoblast is expanded relative to the trophoblast labyrinth
decreased placenta weight ( J:76871 )
• placental weight is decreased relative to controls but greater than in mice homozygous only forIgf2tm1Kel-p

growth/size/body
decreased fetal weight ( J:76871 )
• fetal weight was decreased compared to controls




Genotype
MGI:3845042
cx3
Allelic
Composition		 Phlda2tm2Bty/Phlda2tm2Bty
Phlda3tm1Bty/Phlda3tm1Bty
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Phlda2tm2Bty mutation (0 available); any Phlda2 mutation (9 available)
Phlda3tm1Bty mutation (0 available); any Phlda3 mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
increased placenta weight ( J:76871 )
• placenta weight is shifted upward compared to in wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/07/2025
MGI 6.24 		The Jackson Laboratory