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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hfetm1Sly
targeted mutation 1, William S Sly
MGI:2181388
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hfetm1Sly/Hfetm1Sly Not Specified MGI:3033464
ht2
 		Hfetm1Sly/Hfetm2Sly involves: 129X1/SvJ * C57BL/6J MGI:3033465
cx3
 		Cpm1Cbea/Cpm1Cbea
Hfetm1Sly/Hfetm1Sly 		involves: C3H/DiSnA * C57BL/10ScSnA MGI:3715153


Genotype
MGI:3033464
hm1
Allelic
Composition		 Hfetm1Sly/Hfetm1Sly
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hfetm1Sly mutation (0 available); any Hfe mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased liver iron level ( J:88143 )
• increased in both males and females

liver/biliary system
increased liver iron level ( J:88143 )
• increased in both males and females

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
hemochromatosis type 1 DOID:0111029 OMIM:235200
 J:88143




Genotype
MGI:3033465
ht2
Allelic
Composition		 Hfetm1Sly/Hfetm2Sly
Genetic
Background		 involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hfetm1Sly mutation (0 available); any Hfe mutation (34 available)
Hfetm2Sly mutation (0 available); any Hfe mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased liver iron level ( J:88143 )
• intermediate hepatic iron concentrations
• higher than that of wild-type mice, but lower than that of Hfetm1Sly homozygotes

liver/biliary system
increased liver iron level ( J:88143 )
• intermediate hepatic iron concentrations
• higher than that of wild-type mice, but lower than that of Hfetm1Sly homozygotes

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
hemochromatosis type 1 DOID:0111029 OMIM:235200
 J:88143




Genotype
MGI:3715153
cx3
Allelic
Composition		 Cpm1Cbea/Cpm1Cbea
Hfetm1Sly/Hfetm1Sly
Genetic
Background		 involves: C3H/DiSnA * C57BL/10ScSnA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cpm1Cbea mutation (0 available); any Cp mutation (76 available)
Hfetm1Sly mutation (0 available); any Hfe mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
hemochromatosis ( J:122133 )
• increased liver non-heme iron content




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory