About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bmpr1a+
wild type
MGI:2181348
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Bmpr1atm1Bhr/Bmpr1a+ involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 MGI:4830265
cn2
 		Bmpr1atm2.1Bhr/Bmpr1a+
Tg(Sftpc-cre)1Blh/0 		involves: 129S7/SvEvBrd * C57BL/6 * DBA/2 MGI:3811322
cn3
 		Bmpr1atm2.1Bhr/Bmpr1a+
Tg(Sftpc-cre)1Blh/0 		involves: 129S7/SvEvBrd * C57BL/6 * DBA/2 * ICR MGI:3811314
cn4
 		Bmpr1atm2.1Bhr/Bmpr1a+
Tg(Pou3f4-cre)32Cren/0 		involves: 129S7/SvEvBrd * CD-1 MGI:2181351
cx5
 		Bmpr1atm1Bhr/Bmpr1a+
Col2a1tm1.1Ksec/Col2a1+ 		involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 MGI:4830264
cx6
 		Bmpr1atm1Bhr/Bmpr1a+
Col2a1tm1.1Ksec/Col2a1tm1.1Ksec 		involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 MGI:4830263


Genotype
MGI:4830265
ht1
Allelic
Composition		 Bmpr1atm1Bhr/Bmpr1a+
Genetic
Background		 involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmpr1atm1Bhr mutation (1 available); any Bmpr1a mutation (89 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal neural tube morphology ( J:163739 )
• neural tube deformities are seen in 1 of 11 mice

limbs/digits/tail
abnormal tail morphology ( J:163739 )
• tail deformities are seen in 1 of 11 mice

nervous system
abnormal neural tube morphology ( J:163739 )
• neural tube deformities are seen in 1 of 11 mice




Genotype
MGI:3811322
cn2
Allelic
Composition		 Bmpr1atm2.1Bhr/Bmpr1a+
Tg(Sftpc-cre)1Blh/0
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmpr1atm2.1Bhr mutation (1 available); any Bmpr1a mutation (89 available)
Tg(Sftpc-cre)1Blh mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
respiratory system phenotype ( J:106392 )
N
• Background Sensitivity: unlike on an ICR mixed background, all mice exhibit normal lung morphology




Genotype
MGI:3811314
cn3
Allelic
Composition		 Bmpr1atm2.1Bhr/Bmpr1a+
Tg(Sftpc-cre)1Blh/0
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6 * DBA/2 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmpr1atm2.1Bhr mutation (1 available); any Bmpr1a mutation (89 available)
Tg(Sftpc-cre)1Blh mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
abnormal lung morphology ( J:106392 )
• Background Sensitivity: 46% of mice exhibit lung abnormalities between E16.5, and birth unlike when the transgene is carried on a C57BL/6 background




Genotype
MGI:2181351
cn4
Allelic
Composition		 Bmpr1atm2.1Bhr/Bmpr1a+
Tg(Pou3f4-cre)32Cren/0
Genetic
Background		 involves: 129S7/SvEvBrd * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmpr1atm2.1Bhr mutation (1 available); any Bmpr1a mutation (89 available)
Tg(Pou3f4-cre)32Cren mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype




Genotype
MGI:4830264
cx5
Allelic
Composition		 Bmpr1atm1Bhr/Bmpr1a+
Col2a1tm1.1Ksec/Col2a1+
Genetic
Background		 involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmpr1atm1Bhr mutation (1 available); any Bmpr1a mutation (89 available)
Col2a1tm1.1Ksec mutation (0 available); any Col2a1 mutation (73 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal neural tube morphology ( J:163739 )
• neural tube deformities are seen in 2 of 15 mice

limbs/digits/tail
abnormal tail morphology ( J:163739 )
• tail deformities are seen in 2 of 15 mice

vision/eye
enophthalmos ( J:163739 )
• seen in 1 of 15 mice

nervous system
abnormal neural tube morphology ( J:163739 )
• neural tube deformities are seen in 2 of 15 mice




Genotype
MGI:4830263
cx6
Allelic
Composition		 Bmpr1atm1Bhr/Bmpr1a+
Col2a1tm1.1Ksec/Col2a1tm1.1Ksec
Genetic
Background		 involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmpr1atm1Bhr mutation (1 available); any Bmpr1a mutation (89 available)
Col2a1tm1.1Ksec mutation (0 available); any Col2a1 mutation (73 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:163739 )
• underrepresented at birth and in the embryonic stages

craniofacial
midface hypoplasia ( J:163739 )
• midface hypoplasia is seen in 1 of 1 mice

vision/eye
cyclopia ( J:163739 )
• seen in 1 of 1 mice

growth/size/body
midface hypoplasia ( J:163739 )
• midface hypoplasia is seen in 1 of 1 mice
microcephaly ( J:163739 )
• seen in 1 of 1 mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
01/13/2026
MGI 6.24 		The Jackson Laboratory