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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bmpr1a+
wild type
MGI:2181348
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Bmpr1atm1Bhr/Bmpr1a+ involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 MGI:4830265
cn2
 		Bmpr1atm2.1Bhr/Bmpr1a+
Tg(Sftpc-cre)1Blh/0 		involves: 129S7/SvEvBrd * C57BL/6 * DBA/2 MGI:3811322
cn3
 		Bmpr1atm2.1Bhr/Bmpr1a+
Tg(Sftpc-cre)1Blh/0 		involves: 129S7/SvEvBrd * C57BL/6 * DBA/2 * ICR MGI:3811314
cn4
 		Bmpr1atm2.1Bhr/Bmpr1a+
Tg(Pou3f4-cre)32Cren/0 		involves: 129S7/SvEvBrd * CD-1 MGI:2181351
cx5
 		Bmpr1atm1Bhr/Bmpr1a+
Col2a1tm1.1Ksec/Col2a1+ 		involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 MGI:4830264
cx6
 		Bmpr1atm1Bhr/Bmpr1a+
Col2a1tm1.1Ksec/Col2a1tm1.1Ksec 		involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 MGI:4830263


Genotype
MGI:4830265
ht1
Allelic
Composition		 Bmpr1atm1Bhr/Bmpr1a+
Genetic
Background		 involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmpr1atm1Bhr mutation (1 available); any Bmpr1a mutation (90 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal neural tube morphology ( J:163739 )
• neural tube deformities are seen in 1 of 11 mice

limbs/digits/tail
abnormal tail morphology ( J:163739 )
• tail deformities are seen in 1 of 11 mice

nervous system
abnormal neural tube morphology ( J:163739 )
• neural tube deformities are seen in 1 of 11 mice




Genotype
MGI:3811322
cn2
Allelic
Composition		 Bmpr1atm2.1Bhr/Bmpr1a+
Tg(Sftpc-cre)1Blh/0
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmpr1atm2.1Bhr mutation (1 available); any Bmpr1a mutation (90 available)
Tg(Sftpc-cre)1Blh mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
respiratory system phenotype ( J:106392 )
N
• Background Sensitivity: unlike on an ICR mixed background, all mice exhibit normal lung morphology




Genotype
MGI:3811314
cn3
Allelic
Composition		 Bmpr1atm2.1Bhr/Bmpr1a+
Tg(Sftpc-cre)1Blh/0
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6 * DBA/2 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmpr1atm2.1Bhr mutation (1 available); any Bmpr1a mutation (90 available)
Tg(Sftpc-cre)1Blh mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
abnormal lung morphology ( J:106392 )
• Background Sensitivity: 46% of mice exhibit lung abnormalities between E16.5, and birth unlike when the transgene is carried on a C57BL/6 background




Genotype
MGI:2181351
cn4
Allelic
Composition		 Bmpr1atm2.1Bhr/Bmpr1a+
Tg(Pou3f4-cre)32Cren/0
Genetic
Background		 involves: 129S7/SvEvBrd * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmpr1atm2.1Bhr mutation (1 available); any Bmpr1a mutation (90 available)
Tg(Pou3f4-cre)32Cren mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype




Genotype
MGI:4830264
cx5
Allelic
Composition		 Bmpr1atm1Bhr/Bmpr1a+
Col2a1tm1.1Ksec/Col2a1+
Genetic
Background		 involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmpr1atm1Bhr mutation (1 available); any Bmpr1a mutation (90 available)
Col2a1tm1.1Ksec mutation (0 available); any Col2a1 mutation (70 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal neural tube morphology ( J:163739 )
• neural tube deformities are seen in 2 of 15 mice

limbs/digits/tail
abnormal tail morphology ( J:163739 )
• tail deformities are seen in 2 of 15 mice

vision/eye
enophthalmos ( J:163739 )
• seen in 1 of 15 mice

nervous system
abnormal neural tube morphology ( J:163739 )
• neural tube deformities are seen in 2 of 15 mice




Genotype
MGI:4830263
cx6
Allelic
Composition		 Bmpr1atm1Bhr/Bmpr1a+
Col2a1tm1.1Ksec/Col2a1tm1.1Ksec
Genetic
Background		 involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmpr1atm1Bhr mutation (1 available); any Bmpr1a mutation (90 available)
Col2a1tm1.1Ksec mutation (0 available); any Col2a1 mutation (70 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:163739 )
• underrepresented at birth and in the embryonic stages

craniofacial
midface hypoplasia ( J:163739 )
• midface hypoplasia is seen in 1 of 1 mice

vision/eye
cyclopia ( J:163739 )
• seen in 1 of 1 mice

growth/size/body
midface hypoplasia ( J:163739 )
• midface hypoplasia is seen in 1 of 1 mice
microcephaly ( J:163739 )
• seen in 1 of 1 mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory