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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cry2tm1Jhjh
targeted mutation 1, Jan H J Hoeijmakers
MGI:2181206
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cry2tm1Jhjh/Cry2tm1Jhjh involves: 129P2/OlaHsd * C57BL/6 MGI:4943716
cx2
 		Cry2tm1Jhjh/Cry2tm1Jhjh
Per2tm1Brd/Per2tm1Brd 		involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 MGI:3522463
cx3
 		Cry1tm1Jhjh/Cry1tm1Jhjh
Cry2tm1Jhjh/Cry2+ 		involves: 129P2/OlaHsd * C57BL/6 MGI:4943718
cx4
 		Cry1tm1Jhjh/Cry1+
Cry2tm1Jhjh/Cry2tm1Jhjh 		involves: 129P2/OlaHsd * C57BL/6 MGI:4943717
cx5
 		Cry1tm1Jhjh/Cry1tm1Jhjh
Cry2tm1Jhjh/Cry2tm1Jhjh 		involves: 129P2/OlaHsd * C57BL/6 MGI:4943719


Genotype
MGI:4943716
hm1
Allelic
Composition		 Cry2tm1Jhjh/Cry2tm1Jhjh
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cry2tm1Jhjh mutation (0 available); any Cry2 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal osteoclast physiology ( J:163112 )
• osteoclast activity is decreased compared to in wild-type mice

behavior/neurological
prolonged circadian behavior period ( J:54241 )
• under dark:dark conditions
• however, light entrainment of locomotor activity is normal

immune system
abnormal osteoclast physiology ( J:163112 )
• osteoclast activity is decreased compared to in wild-type mice

hematopoietic system
abnormal osteoclast physiology ( J:163112 )
• osteoclast activity is decreased compared to in wild-type mice




Genotype
MGI:3522463
cx2
Allelic
Composition		 Cry2tm1Jhjh/Cry2tm1Jhjh
Per2tm1Brd/Per2tm1Brd
Genetic
Background		 involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cry2tm1Jhjh mutation (0 available); any Cry2 mutation (43 available)
Per2tm1Brd mutation (1 available); any Per2 mutation (73 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
decreased bone ossification ( J:163112 )
• mice exhibit decreased bone formation rate compared with wild-type mice

behavior/neurological
behavior/neurological phenotype ( J:79492 )
N
• double homozygotes entrain to the LD cycle, displaying locomotor activity patterns similar to those of wild-type
• unexpectedly, double homozygotes are able to maintain a circadian rhythm in DD (rescue of circadian rhythmicity)
• profiles of cycling clock genes in the SCN indicate normal circadian behavior and core oscillator performance




Genotype
MGI:4943718
cx3
Allelic
Composition		 Cry1tm1Jhjh/Cry1tm1Jhjh
Cry2tm1Jhjh/Cry2+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cry1tm1Jhjh mutation (0 available); any Cry1 mutation (39 available)
Cry2tm1Jhjh mutation (0 available); any Cry2 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal circadian behavior ( J:54241 )
• under dark:dark conditions, mice exhibit a shorter free-running rhythm that gradually progresses into arrhythmicity unlike in wild-type mice




Genotype
MGI:4943717
cx4
Allelic
Composition		 Cry1tm1Jhjh/Cry1+
Cry2tm1Jhjh/Cry2tm1Jhjh
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cry1tm1Jhjh mutation (0 available); any Cry1 mutation (39 available)
Cry2tm1Jhjh mutation (0 available); any Cry2 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal circadian behavior period ( J:54241 )
• period is intermediate to single homozygotes




Genotype
MGI:4943719
cx5
Allelic
Composition		 Cry1tm1Jhjh/Cry1tm1Jhjh
Cry2tm1Jhjh/Cry2tm1Jhjh
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cry1tm1Jhjh mutation (0 available); any Cry1 mutation (39 available)
Cry2tm1Jhjh mutation (0 available); any Cry2 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal circadian behavior period ( J:54241 )
• following entrainment to a light:dark regime, mice abruptly adapt to a new situation by starting wheel running as soon as light is off and expanding their period of fragmented activity unlike wild-type mice
arrhythmic circadian behavior persistence ( J:54241 )
• under dark:dark conditions
• however, mice exhibit normal circadian rhythm under light:dark conditions

immune system
abnormal T cell activation ( J:159504 )
• mice exhibit an increase in activated T cells compared with wild-type mice
increased circulating interleukin-1 beta level ( J:159504 )
• following treatment with anti-CII antibodies
increased circulating interleukin-6 level ( J:159504 )
• following treatment with anti-CII antibodies
• however, treatment with anti-TNF-alpha antibodies reduces serum levels of IL6 induced by anti-CII antibodies
increased circulating tumor necrosis factor level ( J:159504 )
• following treatment with anti-CII antibodies
• however, treatment with anti-TNF-alpha antibodies reduces serum levels of TNF-alpha induced by anti-CII antibodies
increased susceptibility to induced arthritis ( J:159504 )
• following treatment with anti-CII antibodies, mice exhibit increased arthritis score and serum levels of TNF-alpha, IL1beta, IL6, and MMP3 compared with wild-type mice
• however, treatment with anti-TNF-alpha antibodies reduces induced arthritis score and levels of TNF-alpha, IL6, and MMP3

skeleton
increased susceptibility to induced arthritis ( J:159504 )
• following treatment with anti-CII antibodies, mice exhibit increased arthritis score and serum levels of TNF-alpha, IL1beta, IL6, and MMP3 compared with wild-type mice
• however, treatment with anti-TNF-alpha antibodies reduces induced arthritis score and levels of TNF-alpha, IL6, and MMP3

homeostasis/metabolism
increased circulating interleukin-1 beta level ( J:159504 )
• following treatment with anti-CII antibodies
increased circulating interleukin-6 level ( J:159504 )
• following treatment with anti-CII antibodies
• however, treatment with anti-TNF-alpha antibodies reduces serum levels of IL6 induced by anti-CII antibodies
increased circulating tumor necrosis factor level ( J:159504 )
• following treatment with anti-CII antibodies
• however, treatment with anti-TNF-alpha antibodies reduces serum levels of TNF-alpha induced by anti-CII antibodies

hematopoietic system
abnormal T cell activation ( J:159504 )
• mice exhibit an increase in activated T cells compared with wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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09/30/2025
MGI 6.24 		The Jackson Laboratory