Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cry2tm1Jhjh mutation
(0 available);
any
Cry2 mutation
(40 available)
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skeleton
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• osteoclast activity is decreased compared to in wild-type mice
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behavior/neurological
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• under dark:dark conditions
• however, light entrainment of locomotor activity is normal
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immune system
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• osteoclast activity is decreased compared to in wild-type mice
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hematopoietic system
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• osteoclast activity is decreased compared to in wild-type mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cry2tm1Jhjh mutation
(0 available);
any
Cry2 mutation
(40 available)
Per2tm1Brd mutation
(1 available);
any
Per2 mutation
(71 available)
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skeleton
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• mice exhibit decreased bone formation rate compared with wild-type mice
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behavior/neurological
N |
• double homozygotes entrain to the LD cycle, displaying locomotor activity patterns similar to those of wild-type
• unexpectedly, double homozygotes are able to maintain a circadian rhythm in DD (rescue of circadian rhythmicity)
• profiles of cycling clock genes in the SCN indicate normal circadian behavior and core oscillator performance
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cry1tm1Jhjh mutation
(0 available);
any
Cry1 mutation
(35 available)
Cry2tm1Jhjh mutation
(0 available);
any
Cry2 mutation
(40 available)
|
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behavior/neurological
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• period is intermediate to single homozygotes
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cry1tm1Jhjh mutation
(0 available);
any
Cry1 mutation
(35 available)
Cry2tm1Jhjh mutation
(0 available);
any
Cry2 mutation
(40 available)
|
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behavior/neurological
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• under dark:dark conditions, mice exhibit a shorter free-running rhythm that gradually progresses into arrhythmicity unlike in wild-type mice
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cry1tm1Jhjh mutation
(0 available);
any
Cry1 mutation
(35 available)
Cry2tm1Jhjh mutation
(0 available);
any
Cry2 mutation
(40 available)
|
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behavior/neurological
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• following entrainment to a light:dark regime, mice abruptly adapt to a new situation by starting wheel running as soon as light is off and expanding their period of fragmented activity unlike wild-type mice
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• under dark:dark conditions
• however, mice exhibit normal circadian rhythm under light:dark conditions
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immune system
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• mice exhibit an increase in activated T cells compared with wild-type mice
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• following treatment with anti-CII antibodies
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• following treatment with anti-CII antibodies
• however, treatment with anti-TNF-alpha antibodies reduces serum levels of IL6 induced by anti-CII antibodies
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• following treatment with anti-CII antibodies
• however, treatment with anti-TNF-alpha antibodies reduces serum levels of TNF-alpha induced by anti-CII antibodies
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• following treatment with anti-CII antibodies, mice exhibit increased arthritis score and serum levels of TNF-alpha, IL1beta, IL6, and MMP3 compared with wild-type mice
• however, treatment with anti-TNF-alpha antibodies reduces induced arthritis score and levels of TNF-alpha, IL6, and MMP3
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skeleton
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• following treatment with anti-CII antibodies, mice exhibit increased arthritis score and serum levels of TNF-alpha, IL1beta, IL6, and MMP3 compared with wild-type mice
• however, treatment with anti-TNF-alpha antibodies reduces induced arthritis score and levels of TNF-alpha, IL6, and MMP3
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homeostasis/metabolism
hematopoietic system
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• mice exhibit an increase in activated T cells compared with wild-type mice
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